Abstract
Neuropsychiatric disorders are devastating mental illnesses with a high economic burden. The additional morbidity associated with social issues that arises along with the course of these diseases increases the need for a clear understanding of their etiopathogenesis to allow an implementation of novel pharmacological strategies. Yet a poor knowledge about interactions occurring at the glia-neuron interface in health and disease still hampers innovative discoveries, despite the fact that glia cells have been long described to actively participate in the regulation of brain circuits.
The purpose of this review was to collect the scattered literature on the involvement of glia cells in neuropsychiatric disorders and to describe how also these cells besides neurons might be responsive to current pharmacological interventions. We hope thereby to offer alternative approaches for investigations that may open avenues to search for new potential targets for drug discovery.
Keywords: Astrocytes, microglia, neuropsychiatric disorders, oligodendrocytes, pharmacotherapy
Current Neuropharmacology
Title:Targeting Glia Cells: Novel Perspectives for the Treatment of Neuropsychiatric Diseases
Volume: 11 Issue: 2
Author(s): B. Di Benedetto and R. Rupprecht
Affiliation:
Keywords: Astrocytes, microglia, neuropsychiatric disorders, oligodendrocytes, pharmacotherapy
Abstract: Neuropsychiatric disorders are devastating mental illnesses with a high economic burden. The additional morbidity associated with social issues that arises along with the course of these diseases increases the need for a clear understanding of their etiopathogenesis to allow an implementation of novel pharmacological strategies. Yet a poor knowledge about interactions occurring at the glia-neuron interface in health and disease still hampers innovative discoveries, despite the fact that glia cells have been long described to actively participate in the regulation of brain circuits.
The purpose of this review was to collect the scattered literature on the involvement of glia cells in neuropsychiatric disorders and to describe how also these cells besides neurons might be responsive to current pharmacological interventions. We hope thereby to offer alternative approaches for investigations that may open avenues to search for new potential targets for drug discovery.
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Cite this article as:
Benedetto Di B. and Rupprecht R., Targeting Glia Cells: Novel Perspectives for the Treatment of Neuropsychiatric Diseases, Current Neuropharmacology 2013; 11 (2) . https://dx.doi.org/10.2174/1570159X11311020004
DOI https://dx.doi.org/10.2174/1570159X11311020004 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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