Abstract
Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity
Current Drug Targets
Title:Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review
Volume: 14 Issue: 4
Author(s): Sinoy Sugunan, Diya Binoy Joseph and G. K. Rajanikant
Affiliation:
Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity
Abstract: Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
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Cite this article as:
Sugunan Sinoy, Binoy Joseph Diya and K. Rajanikant G., Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review, Current Drug Targets 2013; 14 (4) . https://dx.doi.org/10.2174/1389450111314040011
DOI https://dx.doi.org/10.2174/1389450111314040011 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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