Abstract
Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.
Anti-Cancer Agents in Medicinal Chemistry
Title:Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines
Volume: 13 Issue: 10
Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkong and Madalena M. M. Pinto
Affiliation:
Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.
Abstract: Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
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Cite this article as:
Cazal M. Cristiane, Choosang Kantima, Severino Gisele P. Vanessa, Fernandes B. João, Silva Fátima G. F. da Maria, Vieira C. Paulo, Nascimento S. J. Maria, Almeida M. Gabriela, Vasconcelos Helena M., Pakkong Pannee and Pinto M. M. Madalena, Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (10) . https://dx.doi.org/10.2174/1871520613666131125122857
DOI https://dx.doi.org/10.2174/1871520613666131125122857 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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