Inducible Systems for Cell Therapy and Encapsulation Approaches

Author(s): Viktoria Ortner, Cornelius Kaspar and Thomas Czerny

Pp: 93-101 (9)

* (Excluding Mailing and Handling)

Abstract

Encapsulation of heterologous cells allows the production of therapeutic substances selectively in the required tissues of the patient. Thus high local concentrations help to minimise side effects in other parts of the body. Nevertheless, most substances show small therapeutic windows also at their site of action. Furthermore, the timing of the release has to be adjusted to the requirements of the patient and the treatment. Regulation from the outside is therefore necessary to adjust the expression in the transplanted cells.

Keywords: Inducible systems, gene expression, alternating magnetic field, heat shock response, regulated gene expression, heat shock promoter, encapsulation, cell therapy, biological, personalized medicine, temperature increase.