Abstract
Sir2-like proteins, known as sirtuins, have been under a spotlight in the realm of aging because of their positive effect on longevity in Saccharomyces.cerevisiae. Because Sir2 has been identified as a NAD+-dependent histone deacetylase, researchers have attributed its lifespan-extending utilities to gene silencing. Similar phenomena are found in multicellular eukaryotes by seemingly different mechanisms. In mammals, seven sirtuin homologs (SIRT1-7) have been identified, with varied cellular locations and molecular functions. Sirtuins target a wide spectrum of molecules for diversified post-translational modifications, thereby exerting multiple physiological benefits. The roles of sirtuins in cancer are still ambiguous, although they have been extensively studied. In this review, we summarize the multiple physiological roles played by sirtuins and their putative mechanisms, especially in cancer.
Keywords: Sirtuin, post-translational modification, aging, metabolism, genomic stability, apoptosis, autophagy.
Current Pharmaceutical Design
Title:Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis
Volume: 20 Issue: 11
Author(s): Yisha Yao, Yang Yang and Wei-Guo Zhu
Affiliation:
Keywords: Sirtuin, post-translational modification, aging, metabolism, genomic stability, apoptosis, autophagy.
Abstract: Sir2-like proteins, known as sirtuins, have been under a spotlight in the realm of aging because of their positive effect on longevity in Saccharomyces.cerevisiae. Because Sir2 has been identified as a NAD+-dependent histone deacetylase, researchers have attributed its lifespan-extending utilities to gene silencing. Similar phenomena are found in multicellular eukaryotes by seemingly different mechanisms. In mammals, seven sirtuin homologs (SIRT1-7) have been identified, with varied cellular locations and molecular functions. Sirtuins target a wide spectrum of molecules for diversified post-translational modifications, thereby exerting multiple physiological benefits. The roles of sirtuins in cancer are still ambiguous, although they have been extensively studied. In this review, we summarize the multiple physiological roles played by sirtuins and their putative mechanisms, especially in cancer.
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Cite this article as:
Yao Yisha, Yang Yang and Zhu Wei-Guo, Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis, Current Pharmaceutical Design 2014; 20 (11) . https://dx.doi.org/10.2174/13816128113199990513
DOI https://dx.doi.org/10.2174/13816128113199990513 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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