Abstract
Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.
Keywords: Antitumor efficacy, cancer targetability, chitosan/heparin composite, core/shell nanoparticles, enhanced permeability and retention effect, layer-by-layer approach, molecular imaging agent, Pluornics, Pluronic/liposome composite nanoparticles, polyethylene glycol, protein drug, self-assembly, temperature-induced phase transition, vesicle fusion.
Current Medicinal Chemistry
Title:Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis
Volume: 20 Issue: 28
Author(s): Yon Woo Jung, Hwanbum Lee, Jae Yeon Kim, Eun Jin Koo, Keun Sang Oh and Soon Hong Yuk
Affiliation:
Keywords: Antitumor efficacy, cancer targetability, chitosan/heparin composite, core/shell nanoparticles, enhanced permeability and retention effect, layer-by-layer approach, molecular imaging agent, Pluornics, Pluronic/liposome composite nanoparticles, polyethylene glycol, protein drug, self-assembly, temperature-induced phase transition, vesicle fusion.
Abstract: Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.
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Cite this article as:
Jung Woo Yon, Lee Hwanbum, Kim Yeon Jae, Koo Jin Eun, Oh Sang Keun and Yuk Hong Soon, Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis, Current Medicinal Chemistry 2013; 20 (28) . https://dx.doi.org/10.2174/09298673113209990036
DOI https://dx.doi.org/10.2174/09298673113209990036 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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