Abstract
A series of 16 novel 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted-phenyl)pyrimidin-2-ol analogues was synthesized in satisfactory yields after toxicity prediction and drug score studies by Osiris software followed by anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities of 10 compounds by the known reported methods. 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-chlorophenyl)pyrimidin-2-ol (6g) was found to be a potent compound of the series showed good anti-inflammatory (81.91 ± 7.69 % inhibition) and analgesic activity (53.25 ± 2.91) with less ulcerogenic effects (0.66 ± 0.40).
Keywords: Anti-inflammatory activity, Analgesic activity, Osiris software, Pyrazole, Ulcerogenicity.
Letters in Drug Design & Discovery
Title:Synthesis of 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted phenyl)pyrimidin-2-ol Analogues as Anti-Inflammatory and Analgesic Agents
Volume: 10 Issue: 8
Author(s): Muhammad Jahangir Alam, Mohamed Jawed Ahsan, Ozair Alam and Suroor Ahmad Khan
Affiliation:
Keywords: Anti-inflammatory activity, Analgesic activity, Osiris software, Pyrazole, Ulcerogenicity.
Abstract: A series of 16 novel 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted-phenyl)pyrimidin-2-ol analogues was synthesized in satisfactory yields after toxicity prediction and drug score studies by Osiris software followed by anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities of 10 compounds by the known reported methods. 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(4-chlorophenyl)pyrimidin-2-ol (6g) was found to be a potent compound of the series showed good anti-inflammatory (81.91 ± 7.69 % inhibition) and analgesic activity (53.25 ± 2.91) with less ulcerogenic effects (0.66 ± 0.40).
Export Options
About this article
Cite this article as:
Alam Jahangir Muhammad, Ahsan Jawed Mohamed, Alam Ozair and Khan Ahmad Suroor, Synthesis of 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted phenyl)pyrimidin-2-ol Analogues as Anti-Inflammatory and Analgesic Agents, Letters in Drug Design & Discovery 2013; 10 (8) . https://dx.doi.org/10.2174/15701808113100890022
DOI https://dx.doi.org/10.2174/15701808113100890022 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Novel Etomidate Derivatives
Current Pharmaceutical Design Do RAS Inhibitors Protect the Brain from Cerebral Ischemic Injury?
Current Hypertension Reviews Effect of Nitric Oxide Synthase Inhibition on Body Temperature Control During Endotoxemic Shock
Current Enzyme Inhibition Editorial (Hot Topic: Recent Advances in Neonatal Pharmacology)
Current Drug Metabolism Comparing the Molecular Pharmacology of CGRP and Adrenomedullin
Current Protein & Peptide Science Peptide Metabolism and the Control of Body Fluid Homeostasis
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Diagnostic Cardiac Catheterization in the Pediatric Population
Current Cardiology Reviews Turning Foes to Friends: Knocking Down Diabetes Associated SGLT2 Transporters and Sustaining Life
Current Diabetes Reviews Recent Advances in Exercise Testing
Current Cardiology Reviews Effects of Statins on Blood Pressure: A Review of the Experimental and Clinical Evidence.
Current Vascular Pharmacology The Neuroprotective Effect of Ginkgo biloba Leaf Extract and its Possible Mechanism
Central Nervous System Agents in Medicinal Chemistry Role of Antioxidants, Essential Fatty Acids, Carnitine, Vitamins, Phytochemicals and Trace Elements in the Treatment of Diabetes Mellitus and its Chronic Complications
Endocrine, Metabolic & Immune Disorders - Drug Targets Action of the Aqueous Extract of Sesamum Radiatum Schum. & Tonn.(Pedaliaceae) on the Cardiovascular System of Mammalians: Hypotensive Effect
Current Bioactive Compounds Diagnostic Tools, Biomarkers, and Treatments in Diabetic polyneuropathy and Cardiovascular Autonomic Neuropathy
Current Diabetes Reviews Nutritional and Therapeutic Potential of Garlic and Onion (Allium sp.)
Current Nutrition & Food Science Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders
Current Drug Metabolism When and How Should We Cover Patients for Community-Acquired Methicillin-Resistant Staphylococcus aureus (MRSA) Pneumonia?
Current Respiratory Medicine Reviews Studies on Novel Pyridine and 2-pyridone Derivatives of N-arylpiperazine as α-adrenoceptor Ligands
Medicinal Chemistry Challenges in the Management of Paediatric Febrile Neutropenia
Current Pediatric Reviews Recent Applications of Nanomaterials Based on Electrochemical Drug Analysis
Current Analytical Chemistry