Abstract
This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.
Keywords: Application, cancer, delta lactoferrin, lactoferrin, lactoferricin, mechanism, talactoferrin, drug delivery.
Current Protein & Peptide Science
Title:Studies on Anticancer Activities of Lactoferrin and Lactoferricin
Volume: 14 Issue: 6
Author(s): Cui Ming Yin, Jack Ho Wong, Jiang Xia and Tzi Bun Ng
Affiliation:
Keywords: Application, cancer, delta lactoferrin, lactoferrin, lactoferricin, mechanism, talactoferrin, drug delivery.
Abstract: This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.
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Cite this article as:
Yin Ming Cui, Wong Ho Jack, Xia Jiang and Ng Bun Tzi, Studies on Anticancer Activities of Lactoferrin and Lactoferricin, Current Protein & Peptide Science 2013; 14 (6) . https://dx.doi.org/10.2174/13892037113149990066
DOI https://dx.doi.org/10.2174/13892037113149990066 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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