Abstract
Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation. Through selecting alternate (proximal or distal) polyadenylation signals on the 3’-UTR of pre-mRNAs, APA generates multiple transcript isoforms which may even create proteomic diversity. Depending on the use of proximal or distal polyadenylation sites, 3’-UTR lengths can vary in a tightly controlled manner in a spatial and temporal mode. Therefore, APA and its deregulation with potential consequences are highly relevant to normal and disease states. In this review, in light of recent findings in the literature, mechanism and types of APA and roles of APA in biological processes (i.e. proliferation, development, differentiation, and transformation) are discussed.
Keywords: Alternative polyadenylation, APA, microRNA, poly(A) site, 3’-UTR, posttranscriptional regulation.
MicroRNA
Title:Alternative Polyadenylation and Its Impact on Cellular Processes
Volume: 3 Issue: 1
Author(s): Hesna B. Akman and Ayse E. Erson-Bensan
Affiliation:
Keywords: Alternative polyadenylation, APA, microRNA, poly(A) site, 3’-UTR, posttranscriptional regulation.
Abstract: Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation. Through selecting alternate (proximal or distal) polyadenylation signals on the 3’-UTR of pre-mRNAs, APA generates multiple transcript isoforms which may even create proteomic diversity. Depending on the use of proximal or distal polyadenylation sites, 3’-UTR lengths can vary in a tightly controlled manner in a spatial and temporal mode. Therefore, APA and its deregulation with potential consequences are highly relevant to normal and disease states. In this review, in light of recent findings in the literature, mechanism and types of APA and roles of APA in biological processes (i.e. proliferation, development, differentiation, and transformation) are discussed.
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Cite this article as:
B. Akman Hesna and E. Erson-Bensan Ayse, Alternative Polyadenylation and Its Impact on Cellular Processes, MicroRNA 2014; 3 (1) . https://dx.doi.org/10.2174/2211536602666131210001152
DOI https://dx.doi.org/10.2174/2211536602666131210001152 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
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