Abstract
Mycoplasma pneumoniae is an important pathogen of the upper and lower respiratory tracts of children and adults. Historically, it has been susceptible in vitro to macrolides, tetracyclines, and fluoroquinolones. Standardized methods for performance and interpretation of in vitro susceptibility tests have now been published for M. pneumoniae and mechanisms of acquired resistance to macrolides have been shown to be due to mutations in the 23S rRNA gene. Emergence and widespread dissemination of clinically significant high-level macrolide resistance in Asia and documentation of its occurrence to a lesser extent in several European countries and the United States during the past decade is worrisome since treatment options for children are limited. This article summarizes the current status of antimicrobial susceptibility testing, mechanisms of antimicrobial resistance, epidemiology of macrolide resistance and treatment alternatives for pediatric infections caused by M. pneumoniae.
Keywords: Mycoplasma pneumoniae, antimicrobial susceptibility, treatment, antibiotic resistance, macrolide.
Current Pediatric Reviews
Title:Antimicrobial Susceptibilities and Treatment Options for Pediatric Mycoplasma pneumoniae Infections - Does Macrolide Resistance Matter?
Volume: 9 Issue: 4
Author(s): Ken B. Waites
Affiliation:
Keywords: Mycoplasma pneumoniae, antimicrobial susceptibility, treatment, antibiotic resistance, macrolide.
Abstract: Mycoplasma pneumoniae is an important pathogen of the upper and lower respiratory tracts of children and adults. Historically, it has been susceptible in vitro to macrolides, tetracyclines, and fluoroquinolones. Standardized methods for performance and interpretation of in vitro susceptibility tests have now been published for M. pneumoniae and mechanisms of acquired resistance to macrolides have been shown to be due to mutations in the 23S rRNA gene. Emergence and widespread dissemination of clinically significant high-level macrolide resistance in Asia and documentation of its occurrence to a lesser extent in several European countries and the United States during the past decade is worrisome since treatment options for children are limited. This article summarizes the current status of antimicrobial susceptibility testing, mechanisms of antimicrobial resistance, epidemiology of macrolide resistance and treatment alternatives for pediatric infections caused by M. pneumoniae.
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Cite this article as:
Waites B. Ken, Antimicrobial Susceptibilities and Treatment Options for Pediatric Mycoplasma pneumoniae Infections - Does Macrolide Resistance Matter?, Current Pediatric Reviews 2013; 9 (4) . https://dx.doi.org/10.2174/157339630904131223104312
DOI https://dx.doi.org/10.2174/157339630904131223104312 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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