Abstract
Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for the treatment of infections throughout the body rather than for delivering high concentrations locally within the stomach. Many gastroretentive dosage forms were developed in order to eradicate the infection, yet additional advancements are still needed to eliminate the infection completely and decrease its prevalence worldwide. An overview on different antimicrobials and a literature survey about different drug delivery systems used in eradication of H. pylori infection are presented in this review.
Keywords: Gastroretentive, Helicobacter pylori, Mucopenetration, Specific targeting.
Current Drug Delivery
Title:Helicobacter pylori: An Overview on Antimicrobials and Drug Delivery Systems for its Eradication
Volume: 11 Issue: 3
Author(s): Sally A. El-Zahaby, Abeer A. Kassem and Amal H. El-Kamel
Affiliation:
Keywords: Gastroretentive, Helicobacter pylori, Mucopenetration, Specific targeting.
Abstract: Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for the treatment of infections throughout the body rather than for delivering high concentrations locally within the stomach. Many gastroretentive dosage forms were developed in order to eradicate the infection, yet additional advancements are still needed to eliminate the infection completely and decrease its prevalence worldwide. An overview on different antimicrobials and a literature survey about different drug delivery systems used in eradication of H. pylori infection are presented in this review.
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Cite this article as:
El-Zahaby A. Sally, Kassem A. Abeer and El-Kamel H. Amal, Helicobacter pylori: An Overview on Antimicrobials and Drug Delivery Systems for its Eradication, Current Drug Delivery 2014; 11 (3) . https://dx.doi.org/10.2174/1567201811666140327145049
DOI https://dx.doi.org/10.2174/1567201811666140327145049 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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