Abstract
In vivo electroporation is one of the most efficient methods for introducing the nucleic acids into the target tissues, and thus plays a pivotal role in gene therapeutic studies. In vivo electroporation in rodent brains is often involved in injection of nucleic acids into the brain ventricle or specific area and then applying appropriate electrical field to the correct area. Better understanding of the progress of electroporation in rodent brain may further facilitate gene therapeutic studies on some brain disorders. For this purpose, we briefly summarized the advantages, the procedures and recent progress of transferring nucleic acids into the rodent brain using in vivo electroporation.
Keywords: Bilateral electroporation, brain disorder, gene therapy, in vivo electroporation, rodent brain.
Current Gene Therapy
Title:Progress of In Vivo Electroporation in the Rodent Brain
Volume: 14 Issue: 3
Author(s): Xue-Feng Ding, De-Lin Ma, Qiang Zhang, Wei Peng, Ming Fan and William Z. Suo
Affiliation:
Keywords: Bilateral electroporation, brain disorder, gene therapy, in vivo electroporation, rodent brain.
Abstract: In vivo electroporation is one of the most efficient methods for introducing the nucleic acids into the target tissues, and thus plays a pivotal role in gene therapeutic studies. In vivo electroporation in rodent brains is often involved in injection of nucleic acids into the brain ventricle or specific area and then applying appropriate electrical field to the correct area. Better understanding of the progress of electroporation in rodent brain may further facilitate gene therapeutic studies on some brain disorders. For this purpose, we briefly summarized the advantages, the procedures and recent progress of transferring nucleic acids into the rodent brain using in vivo electroporation.
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Cite this article as:
Ding Xue-Feng, Ma De-Lin, Zhang Qiang, Peng Wei, Fan Ming and Suo Z. William, Progress of In Vivo Electroporation in the Rodent Brain, Current Gene Therapy 2014; 14 (3) . https://dx.doi.org/10.2174/1566523214666140424145305
DOI https://dx.doi.org/10.2174/1566523214666140424145305 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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