Abstract
Amniotic fluid embolism (AFE) is a serious obstetric emergency, burdened with a high rate of mortality and morbidity and possible permanent neurological sequelae for those women who survive. The clinical presentation commonly includes: acute hypotension or cardiac arrest, acute hypoxia (dyspnea, cyanosis or respiratory arrest) and coagulopathy (intravascular coagulation or severe haemorrhage), which usually occur during labour, caesarean section or within 30 minutes of delivery. Some cases for the rapidity of clinical presentation, which can result in fatal outcome, run the risk of not being recognized, therefore a proper post mortem examination and histological investigation is fundamental in case of maternal death in order to make the diagnosis and should not be underestimated the incidence of this serious pathological condition. In this paper, firstly the Authors investigated the fatality rates in AFE patients and its incidence in pregnancy related deaths, extrapolating epidemiological data regarding the role of this pathology among the leading causes of maternal mortality. Secondly the contribution of autopsy has been evaluated and further investigation performed on post mortem in order to confirm or make the diagnosis of AFE to better understand this clinical entity that still remains unclear under numerous aspects.
Keywords: Amniotic fluid embolism, autopsy and histology, pregnancy related deaths.
Current Pharmaceutical Biotechnology
Title:Epidemiological and Clinical Data of Amniotic Fluid Embolism in Forensic Settings
Volume: 14 Issue: 14
Author(s): Francesco P. Busardo, Paola Frati, Steven B. Karch and Vittorio Fineschi
Affiliation:
Keywords: Amniotic fluid embolism, autopsy and histology, pregnancy related deaths.
Abstract: Amniotic fluid embolism (AFE) is a serious obstetric emergency, burdened with a high rate of mortality and morbidity and possible permanent neurological sequelae for those women who survive. The clinical presentation commonly includes: acute hypotension or cardiac arrest, acute hypoxia (dyspnea, cyanosis or respiratory arrest) and coagulopathy (intravascular coagulation or severe haemorrhage), which usually occur during labour, caesarean section or within 30 minutes of delivery. Some cases for the rapidity of clinical presentation, which can result in fatal outcome, run the risk of not being recognized, therefore a proper post mortem examination and histological investigation is fundamental in case of maternal death in order to make the diagnosis and should not be underestimated the incidence of this serious pathological condition. In this paper, firstly the Authors investigated the fatality rates in AFE patients and its incidence in pregnancy related deaths, extrapolating epidemiological data regarding the role of this pathology among the leading causes of maternal mortality. Secondly the contribution of autopsy has been evaluated and further investigation performed on post mortem in order to confirm or make the diagnosis of AFE to better understand this clinical entity that still remains unclear under numerous aspects.
Export Options
About this article
Cite this article as:
Busardo P. Francesco, Frati Paola, Karch B. Steven and Fineschi Vittorio, Epidemiological and Clinical Data of Amniotic Fluid Embolism in Forensic Settings, Current Pharmaceutical Biotechnology 2013; 14 (14) . https://dx.doi.org/10.2174/1389201015666140430153717
DOI https://dx.doi.org/10.2174/1389201015666140430153717 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Inhibitors of Nitric Oxide Synthase: What's up and What's Next?
Current Enzyme Inhibition Sodium Carbonate Sesquiperhydrate (2Na2CO3-3H2O2) Catalysed One-pot Synthesis of Biologically Dynamic Novel Substituted Spirooxirane Dicarboxamides
Current Catalysis Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation
Current Neuropharmacology Prevention and Management of Ovarian Hyperstimulation Syndrome
Current Women`s Health Reviews Melanocortins in the Treatment of Male and Female Sexual Dysfunction
Current Topics in Medicinal Chemistry Schizophrenia: Causes and Treatments
Current Pharmaceutical Design New Developments in Systemic Therapy for Hepatocellular Carcinoma
Current Cancer Therapy Reviews ATP-Sensitive Potassium Channels
Current Pharmaceutical Design Micropropagation: A Tool for the Production of High Quality Plant-based Medicines
Current Pharmaceutical Biotechnology The Cancer Related Thrombotic Tendency in Sepsis
Current Drug Targets Safety Considerations of the Use of Second Generation Antipsychotics in the Treatment of Major Depression: Extrapyramidal and Metabolic Side Effects
Current Drug Safety Kinins as Therapeutic Agents in Cardiovascular and Renal Diseases
Current Pharmaceutical Design Evidence that Cortical Dopamine is a Co-Transmitter in Noradrenergic Neurons
Current Psychiatry Reviews Role of Cyclic Tertiary Amine Bioactivation to Reactive Iminium Species: Structure Toxicity Relationship
Current Drug Metabolism Prevention and Repair of Circulatory Shock and Cerebral Ischemia/Injury by Various Agents in Experimental Heatstroke
Current Medicinal Chemistry Advances in L-Type Calcium Channel Structures, Functions and Molecular Modeling
Current Medicinal Chemistry Noncardiac Surgery: Evaluating and Minimizing Cardiac Risk
Current Cardiology Reviews What is the Optimal Treatment for Anemia in Inflammatory Bowel Disease?
Current Drug Delivery How Could We Reduce Antibiotic Use in Critically Ill Patients?
Infectious Disorders - Drug Targets Pharmacological Management of Type 2 Diabetes Mellitus: An Update
Current Diabetes Reviews