Abstract
The oral delivery of therapeutics is of paramount importance to medical application and advancement. There has been remarkable advancement in the field of polymeric formulations for oral delivery of therapeutics. Novel polymeric formulation like polymeric nanoparticles, micelles and dendrimers are exploited and researched to further improve the bioavailability, stability, permeability and therapeutic efficacy. Over the last years, there have been number of approaches used for the effective delivery of bioactive(s). These include chemical modification, use of enzyme inhibitors and permeation enhancers, and novel drug delivery systems. Numerous polymeric nanoarchitectures based strategies are able to overcome restrictions and show the promising approach for efficient [P/P] drugs oral delivery. The aim of present review focuses on the need for the development of polymeric nanocarrier for oral-peptide and protein delivery with emphases on insulin delivery via various polymeric nanocarriers.
Keywords: Caco-2 cell monolayers, dendrimers, nanoparticles, oral delivery.
Current Drug Therapy
Title:Polymeric Nanocarriers for the Oral Delivery of Bioactives
Volume: 9 Issue: 1
Author(s): Rajeev Sharma, Udita Agrawal and Suresh P. Vyas
Affiliation:
Keywords: Caco-2 cell monolayers, dendrimers, nanoparticles, oral delivery.
Abstract: The oral delivery of therapeutics is of paramount importance to medical application and advancement. There has been remarkable advancement in the field of polymeric formulations for oral delivery of therapeutics. Novel polymeric formulation like polymeric nanoparticles, micelles and dendrimers are exploited and researched to further improve the bioavailability, stability, permeability and therapeutic efficacy. Over the last years, there have been number of approaches used for the effective delivery of bioactive(s). These include chemical modification, use of enzyme inhibitors and permeation enhancers, and novel drug delivery systems. Numerous polymeric nanoarchitectures based strategies are able to overcome restrictions and show the promising approach for efficient [P/P] drugs oral delivery. The aim of present review focuses on the need for the development of polymeric nanocarrier for oral-peptide and protein delivery with emphases on insulin delivery via various polymeric nanocarriers.
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Sharma Rajeev, Agrawal Udita and Vyas P. Suresh, Polymeric Nanocarriers for the Oral Delivery of Bioactives, Current Drug Therapy 2014; 9 (1) . https://dx.doi.org/10.2174/1574885509666140805004615
DOI https://dx.doi.org/10.2174/1574885509666140805004615 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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