Abstract
Cancer is the manifestation of multiple dysregulated cellular pathways. Treatment protocols engaged in treating these diseases involve mainly the cell cycle regulating genes/proteins, DNA synthesis and repair, protein synthetic machinery, apoptotic and proliferation activity and cytoskeletal framework. Some of the traditional therapeutic strategies have over the years developed resistance making cure difficult to achieve. This paper analyzes the mechanisms employed by various cancers that render them resistant against therapeutic drugs.
Keywords: Cancer, drug, mutation, radiation, resistance, therapeutics.
Current Pharmaceutical Biotechnology
Title:Mechanisms of Resistance Against Cancer Therapeutic Drugs
Volume: 15 Issue: 12
Author(s): Shailja Chatterjee, Satyawan G. Damle and Anil K. Sharma
Affiliation:
Keywords: Cancer, drug, mutation, radiation, resistance, therapeutics.
Abstract: Cancer is the manifestation of multiple dysregulated cellular pathways. Treatment protocols engaged in treating these diseases involve mainly the cell cycle regulating genes/proteins, DNA synthesis and repair, protein synthetic machinery, apoptotic and proliferation activity and cytoskeletal framework. Some of the traditional therapeutic strategies have over the years developed resistance making cure difficult to achieve. This paper analyzes the mechanisms employed by various cancers that render them resistant against therapeutic drugs.
Export Options
About this article
Cite this article as:
Chatterjee Shailja, Damle G. Satyawan and Sharma K. Anil, Mechanisms of Resistance Against Cancer Therapeutic Drugs, Current Pharmaceutical Biotechnology 2014; 15 (12) . https://dx.doi.org/10.2174/1389201015666141126123952
DOI https://dx.doi.org/10.2174/1389201015666141126123952 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Role and Pharmacogenomics of TNF-α in Asthma
Mini-Reviews in Medicinal Chemistry Potential Therapeutic Relevance of Adenosine A2B and A2A Receptors in the Central Nervous System
CNS & Neurological Disorders - Drug Targets Eidtorial from Editor-in-Chief (Breast Cancer: Still a Pending Issue where Much Effort is Needed)
Current Women`s Health Reviews Rational Design and Development of RDP58
Current Pharmaceutical Design Bismuth-213 and Actinium-225 – Generator Performance and Evolving Therapeutic Applications of Two Generator-Derived Alpha-Emitting Radioisotopes
Current Radiopharmaceuticals LncRNA SNHG7 Serves as a Potential Biomarker on the Prognosis of Human Solid Tumors: A Meta-Analysis
Current Pharmaceutical Biotechnology Evolution of Ipsilateral Head and Neck Radiotherapy
Current Cancer Therapy Reviews Drug Targeting Systems for Cancer Therapy: Nanotechnological Approach
Mini-Reviews in Medicinal Chemistry 89Zr Radiochemistry for Positron Emission Tomography
Medicinal Chemistry Old Drugs-Current Perspectives
Current Pharmacogenomics The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs
Current Pharmaceutical Design Nanoparticles for Gene Delivery: A Brief Patent Review
Recent Patents on Drug Delivery & Formulation Economics of Pharmacogenomics: Rethinking Beyond QALYs?
Current Pharmacogenomics and Personalized Medicine Mitochondrial Permeability Transition as Target of Anticancer Drugs
Current Pharmaceutical Design Anti-cancer Therapies in High Grade Gliomas
Current Proteomics Detection of Predictive Markers for Therapeutic Stratification of Salivary Glands Tumors
Current Drug Targets Can an Apple a Day Keep the Doctor Away?
Current Pharmaceutical Design Carbon Nanotubes: Materials for Medicinal Chemistry and Biotechnological Applications
Current Medicinal Chemistry Role of microRNAs in Gynecological Pathology
Current Medicinal Chemistry Genito-Urological Cancers in Elderly Patients
Anti-Cancer Agents in Medicinal Chemistry