Abstract
Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death. Antioxidant supplements are consumed widely by cancer patients in order to prevent toxic side effects of cancer treatment to normal tissues and organs. However, the effects of antioxidant supplementation in cancer therapy were largely disappointing. There is still no consensus on the efficacy and safety of dietary antioxidant supplementation during conventional cancer therapy. In some studies, antioxidant supplements did not reduce the risk for cancer or prevent tumour growth; at the contrary, these interventions resulted in some cases to be harmful to the patients. Therefore, a guidance on antioxidant supplementation based on large clinical trials is urgently needed in order to obtain the best possible care and to avoid risky treatments for cancer patients.
Keywords: Antioxidants, Cancer, Chemotherapeutic agents, Oxidative stress, Radiation, Reactive oxygen species, Supplements.
Current Topics in Medicinal Chemistry
Title:Antioxidant Supplementation on Cancer Risk and During Cancer Therapy: An Update
Volume: 15 Issue: 2
Author(s): Tomris Ozben
Affiliation:
Keywords: Antioxidants, Cancer, Chemotherapeutic agents, Oxidative stress, Radiation, Reactive oxygen species, Supplements.
Abstract: Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death. Antioxidant supplements are consumed widely by cancer patients in order to prevent toxic side effects of cancer treatment to normal tissues and organs. However, the effects of antioxidant supplementation in cancer therapy were largely disappointing. There is still no consensus on the efficacy and safety of dietary antioxidant supplementation during conventional cancer therapy. In some studies, antioxidant supplements did not reduce the risk for cancer or prevent tumour growth; at the contrary, these interventions resulted in some cases to be harmful to the patients. Therefore, a guidance on antioxidant supplementation based on large clinical trials is urgently needed in order to obtain the best possible care and to avoid risky treatments for cancer patients.
Export Options
About this article
Cite this article as:
Ozben Tomris, Antioxidant Supplementation on Cancer Risk and During Cancer Therapy: An Update, Current Topics in Medicinal Chemistry 2015; 15 (2) . https://dx.doi.org/10.2174/1568026615666141209160918
DOI https://dx.doi.org/10.2174/1568026615666141209160918 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Oxido-reductase Activity of the Apoptosis Inducing Factor: A Promising Pharmacological Tool?
Current Pharmaceutical Design Targeting the Inflammatory Response in Healing Myocardial Infarcts
Current Medicinal Chemistry Ferroptotic Cell Death: New Regulatory Mechanisms for Metabolic Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus
Current Neurovascular Research Folding, Assembly, and Stability of Transmembrane Cytochromes
Current Chemical Biology Emerging Indications for Statins: A Pluripotent Family of Agents with Several Potential Applications
Current Pharmaceutical Design Toxics of Tobacco Smoke and Cardiovascular System: From Functional to Cellular Damage
Current Pharmaceutical Design Potential New Targets for Antithrombotic Therapy
Current Pharmaceutical Design The Pattern of Calculated Inflammation Ratios as Prognostic Values in Patients with Colorectal Cancer
Combinatorial Chemistry & High Throughput Screening Restriction Factors Against Recombinant Adeno-associated Virus Vectormediated Gene Transfer in Dystrophin-deficient Muscles
Current Gene Therapy Omecamtiv Mecarbil: A Myosin Motor Activator Agent with Promising Clinical Performance and New in vitro Results
Current Medicinal Chemistry Oxidative Stress, Endothelial Dysfunction and Atherosclerosis
Current Pharmaceutical Design Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease
Current Vascular Pharmacology Tissue Doppler Imaging: Beautiful Noise
Current Cardiology Reviews Role of Cardiolipin in Mitochondrial Diseases and Apoptosis
Current Medicinal Chemistry Cardiac Regeneration: Stem Cells and Beyond
Current Medicinal Chemistry Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress- Mediated Hyperglycemia
Current Neurovascular Research P2X Receptors in the Cardiovascular System and their Potential as Therapeutic Targets in Disease
Current Medicinal Chemistry Heme Oxygenase-1/CO as Protective Mediators in Cigarette Smoke- Induced Lung Cell Injury and Chronic Obstructive Pulmonary Disease
Current Pharmaceutical Biotechnology Angiogenesis and the Heart
Recent Patents on Cardiovascular Drug Discovery