Abstract
The maintenance of pancreatic β-cells normal functioning is crucial for insulin production and glucose homeostasis. Inadequate insulin secretion due to β-cell dysfunction can lead to different types of diabetes mellitus. Though it is widely recognized that both environmental and genetic factors play important roles, the exact molecular mechanism that leads to β -cell failure is still unclear. MicroRNAs (miRNAs) regulate numerous physiological and pathophysiological processes at the epigenetic level. miRNAs have been reported to participate in the process of pancreatic development and insulin biosynthesis. Some miRNAs may control insulin secretion and exocytosis through regulating ATP/ADP ratio. In this review, we will summarize the pathological roles of miRNAs in β-cell dysfunction and briefly discuss miRNAs as possible biomarkers and potential pharmaceutical target for diabetes mellitus.
Current Signal Transduction Therapy
Title:MicroRNAs in Diabetic β Cell Dysfunction and their Role as Biomarkers
Volume: 9 Issue: 2
Author(s): Yaxi Chen, Haoming Tian and Xijie Yu
Affiliation:
Keywords: Biomarker, β cells, diabetes, insulin, miRNAs.
Abstract: The maintenance of pancreatic β-cells normal functioning is crucial for insulin production and glucose homeostasis. Inadequate insulin secretion due to β-cell dysfunction can lead to different types of diabetes mellitus. Though it is widely recognized that both environmental and genetic factors play important roles, the exact molecular mechanism that leads to β -cell failure is still unclear. MicroRNAs (miRNAs) regulate numerous physiological and pathophysiological processes at the epigenetic level. miRNAs have been reported to participate in the process of pancreatic development and insulin biosynthesis. Some miRNAs may control insulin secretion and exocytosis through regulating ATP/ADP ratio. In this review, we will summarize the pathological roles of miRNAs in β-cell dysfunction and briefly discuss miRNAs as possible biomarkers and potential pharmaceutical target for diabetes mellitus.
Export Options
About this article
Cite this article as:
Chen Yaxi, Tian Haoming and Yu Xijie, MicroRNAs in Diabetic β Cell Dysfunction and their Role as Biomarkers, Current Signal Transduction Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574362410666150114230309
DOI https://dx.doi.org/10.2174/1574362410666150114230309 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effects of Mefepronic Acid (2-Phenoxy-2-Methyl Propionic Acid) on Hepatic Metabolism and Reproductive Parameters in Postpartum Dairy Cows
Endocrine, Metabolic & Immune Disorders - Drug Targets Diabetes, Sexual Dysfunction and Therapeutic Exercise: A 20 Year Review
Current Diabetes Reviews Weight Loss in Older Persons: New Therapeutic Approaches
Current Pharmaceutical Design Underlying Pathways for Interferon Risk to Type II Diabetes Mellitus
Current Diabetes Reviews Essential Fatty Acids - A Review
Current Pharmaceutical Biotechnology Preconception Care for Diabetic Women: Background, Barriers, and Strategies for Effective Implementation
Current Diabetes Reviews Hypertension in Pregnancy: A Review of Current Guidelines
Current Women`s Health Reviews Hypertension and Atrial Fibrillation: Any Change with the New Anticoagulants
Current Pharmaceutical Design Psoriasis and Vascular Risk : An Update
Current Pharmaceutical Design Cardiac Aging and Insulin Resistance: Could Insulin/Insulin-Like Growth Factor (IGF) Signaling be used as a Therapeutic Target?
Current Pharmaceutical Design Natural Antioxidants in Wheat Sprout Extracts
Current Organic Chemistry Protein Kinase C – Possible Therapeutic Target to Treat Cardiovascular Diseases
Cardiovascular & Hematological Disorders-Drug Targets Protective Effect of Vitamin B Therapy on Bone and Cardiovascular Disease
Recent Patents on Cardiovascular Drug Discovery Dietary Patterns and Prevention of Type 2 Diabetes: From Research to Clinical Practice; A Systematic Review
Current Diabetes Reviews Is Glyburide Safe in Pregnancy?
Current Pharmaceutical Biotechnology Reduction of Myocardial Ischemia-Reperfusion Injury with Pre- and Postconditioning: Molecular Mechanisms and Therapeutic Targets
Cardiovascular & Hematological Disorders-Drug Targets Triglycerides and Vascular Risk: Insights from Epidemiological Data and Interventional Studies
Current Drug Targets Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective
Current Pharmaceutical Design Importance of Dietary Supplements to the Health
Current Nutrition & Food Science Substance Abuse, HIV-1 and Hepatitis
Current HIV Research