Abstract
Cytochromes P450 enzymes, especially CYP3A4, are responsible for metabolizing a broad range of anticancer drugs. Combination therapy is common in patients with cancer, which may cause potential drug drug interactions (DDIs) leading to increased risk of side-effects/toxicity or decreased effectiveness. The review summarizes CYP3A4-mediated DDIs, with anticancer drugs as CYP3A4 substrates or modulators, in clinical trials during cancer therapy and aims to increase clinicians' awareness to take caution to reduce the risk.
Keywords: Anticancer drugs, cytochromes P450 (CYP) enzymes, drug-drug interactions, pharmacokinetics.
Current Drug Metabolism
Title:CYP3A4-mediated Pharmacokinetic Interactions in Cancer Therapy
Volume: 15 Issue: 8
Author(s): Dandan Tian and Zheyi Hu
Affiliation:
Keywords: Anticancer drugs, cytochromes P450 (CYP) enzymes, drug-drug interactions, pharmacokinetics.
Abstract: Cytochromes P450 enzymes, especially CYP3A4, are responsible for metabolizing a broad range of anticancer drugs. Combination therapy is common in patients with cancer, which may cause potential drug drug interactions (DDIs) leading to increased risk of side-effects/toxicity or decreased effectiveness. The review summarizes CYP3A4-mediated DDIs, with anticancer drugs as CYP3A4 substrates or modulators, in clinical trials during cancer therapy and aims to increase clinicians' awareness to take caution to reduce the risk.
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Cite this article as:
Tian Dandan and Hu Zheyi, CYP3A4-mediated Pharmacokinetic Interactions in Cancer Therapy, Current Drug Metabolism 2014; 15 (8) . https://dx.doi.org/10.2174/1389200216666150223152627
DOI https://dx.doi.org/10.2174/1389200216666150223152627 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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