Abstract
Nano-machine-module is designed and synthesized as a futuristic drug (PCMS) for cancer and Alzheimers by doping 2 Nile Red molecules in the cavity of a 5th generation PAM AM dendrimer P, and attaching 32 molecular rotors M, 4 pH sensors S on its surface. Molecular rotors and sensors enable the dendritic box surface to target specific sites, minimizing termination of healthy cells, e.g. cancer cells, nuclei acids (DNA) & spirals of Abeta Amyloid are disintegrated. Combined Excitation Emission Spectroscopy (CEES) shows directed energy transfer along M↔C↔S, this energy transmission path is itself an oscillation, and we image live resonant oscillation of the PCMS and the target molecular system. PCMS engages into resonant oscillations with spiral molecular structures. PCMS is designed to sense microsatellite instability & spirals with resonance frequencies in the kHz range. PCM is toxic, but the toxicity disappears as S is added to derive PCMS. PCMS does not even affect the dynamic instability of microtubule, a basic operator of living cells.
Keywords: Alzheimer, Cancer, Dendrimer, Dendritic box, Electromagnetic resonance, Electromagnetic treatment, Medicine, Molecular machine, sensor.
Current Topics in Medicinal Chemistry
Title:Resonant Oscillation Language of a Futuristic Nano-Machine-Module: Eliminating Cancer Cells & Alzheimer Aβ Plaques
Volume: 15 Issue: 6
Author(s): Subrata Ghosh, Somnath Chatterjee, Anirban Roy, Kanad Ray, Snehasikta Swarnakar, Daisuke Fujita and Anirban Bandyopadhyay
Affiliation:
Keywords: Alzheimer, Cancer, Dendrimer, Dendritic box, Electromagnetic resonance, Electromagnetic treatment, Medicine, Molecular machine, sensor.
Abstract: Nano-machine-module is designed and synthesized as a futuristic drug (PCMS) for cancer and Alzheimers by doping 2 Nile Red molecules in the cavity of a 5th generation PAM AM dendrimer P, and attaching 32 molecular rotors M, 4 pH sensors S on its surface. Molecular rotors and sensors enable the dendritic box surface to target specific sites, minimizing termination of healthy cells, e.g. cancer cells, nuclei acids (DNA) & spirals of Abeta Amyloid are disintegrated. Combined Excitation Emission Spectroscopy (CEES) shows directed energy transfer along M↔C↔S, this energy transmission path is itself an oscillation, and we image live resonant oscillation of the PCMS and the target molecular system. PCMS engages into resonant oscillations with spiral molecular structures. PCMS is designed to sense microsatellite instability & spirals with resonance frequencies in the kHz range. PCM is toxic, but the toxicity disappears as S is added to derive PCMS. PCMS does not even affect the dynamic instability of microtubule, a basic operator of living cells.
Export Options
About this article
Cite this article as:
Ghosh Subrata, Chatterjee Somnath, Roy Anirban, Ray Kanad, Swarnakar Snehasikta, Fujita Daisuke and Bandyopadhyay Anirban, Resonant Oscillation Language of a Futuristic Nano-Machine-Module: Eliminating Cancer Cells & Alzheimer Aβ Plaques, Current Topics in Medicinal Chemistry 2015; 15 (6) . https://dx.doi.org/10.2174/1568026615666150225101155
DOI https://dx.doi.org/10.2174/1568026615666150225101155 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Artificial intelligence for Natural Products Discovery and Development
Our approach involves using computational methods to predict the potential therapeutic benefits of natural products by considering factors such as drug structure, targets, and interactions. We also employ multitarget analysis to understand the role of drug targets in disease pathways. We advocate for the use of artificial intelligence in predicting ...read more
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Hypertension and Cardiac Arrhythmias
Current Pharmaceutical Design Subject Index to Volume 2
Current Neuropharmacology Antioxidant Activity of Thio-Schiff Bases
Letters in Drug Design & Discovery Resident Kidney Cells and Their Involvement in Glomerulonephritis
Current Drug Targets - Inflammation & Allergy Crohns Targeted Therapy: Myth or Real Goal?
Current Drug Discovery Technologies Editorial:
Neuroscience and Biomedical Engineering (Discontinued) Inhibition of Rho/Rho-Kinase as Therapeutic Strategy to Promote CNS Axonal Regeneration
Central Nervous System Agents in Medicinal Chemistry The Role of Adenosine in Alzheimers Disease
Current Neuropharmacology Prospect of a Dopamine Contribution in the Next Generation of Antidepressant Drugs: The Triple Reuptake Inhibitors
Current Drug Targets Congenital Cytomegalovirus Prevention, Awareness and Policy Recommendations - A Scoping Study
Infectious Disorders - Drug Targets Anti-obesity Agents: A Focused Review on the Structural Classification of Therapeutic Entities
Current Topics in Medicinal Chemistry Preface
Central Nervous System Agents in Medicinal Chemistry CYP Inhibition-Mediated Drug-Drug Interactions
Current Enzyme Inhibition Prenatal Pregabalin Exposure Alters Postnatal Pain Sensitivity and Some Behavioral Responses in Adult Offspring Rats
Current Drug Safety Pan-Amyloid Oligomer Specific scFv Antibody Attenuates Memory Deficits and Brain Amyloid Burden in Mice with Alzheimer’s Disease
Current Alzheimer Research The Effects of Curcumin on Immune Responses
Current Bioactive Compounds Intracellular Fate of Peptide-Mediated Delivered Cargoes
Current Pharmaceutical Design Growing Use of Conventional Methods for Preparation of Scaffolds for Bone Tissue Engineering
Current Applied Polymer Science New Prospects for the Drug Treatment of Generalized Anxiety Disorder — A Systematic Review
Current Drug Therapy Pilot Study of the Reducing Effect on Amyloidosis In Vivo by Three FDA Pre-Approved Drugs Via the Alzheimers APP 5Untranslated Region
Current Alzheimer Research