Abstract
In the present investigation, the extraction of ginger (Zingiber officinale Roscoe) rhizome using a new potential green solvents. 6-Gingerol is the major bioactive constituent responsible for the anti-inflammatory, antitumor and antioxidant activities of ginger. The 6-gingerol related compounds was successfully extracted and isolated from Zingiber officinale Roscoe using Natural deep eutectic solvents (NADES) and compared extraction activity with organic solvents. Different combination of NADES was synthesized using evaporating and heating methods. The gingerol related compounds was characterized by using various instrumental methods like UV spectroscopy, FTIR, HPLC and NMR. The FTIR was confirmed presence of gingerols, shogoals and some other essential oils in different NADES extracts. HPLC analysis showed the major presence of gingerols, shogaols and minor existence of essential oils in ginger extracts. Chemical shift values of gingerol and shogaol structure were well fitted with the 1H and 13C NMR spectrum. The antioxidant activity of the NADES extracts was higher than the organic solvent extracts. From different combination of NADES extracts, L-Proline and lactic acid (1:1) combination having a higher antioxidant capacity than other three NADES combinations. Antimicrobial activity of four NADESs, ethanol and chloroform of Zingiber officinale Roscoe rhizome were evaluated using agar disc diffusion methods.
Keywords: Ginger, gingerol, natural deep eutectic solvents, organic solvents, shogaol.
Graphical Abstract
Call for Papers in Thematic Issues
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Current Analytical Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Combinatorial Chemistry & High Throughput Screening
Current Organic Chemistry
Current Medicinal Chemistry
Current Organic Synthesis
Central Nervous System Agents in Medicinal Chemistry
Mini-Reviews in Organic Chemistry
Related Books
Botanicals and Natural Bioactives: Prevention and Treatment of Diseases
Biosurfactants: A Boon to Healthcare, Agriculture & Environmental Sustainability
Advances in Dye Degradation
Biological and Medical Significance of Chemical Elements
Frontiers In Medicinal Chemistry
Advances in Organic Synthesis
Frontiers in Natural Product Chemistry
Recent Advances in Analytical Techniques
Advanced Catalysts Based on Metal-organic Frameworks (Part 2)
Ionic Liquids: Eco-friendly Substitutes for Surface and Interface Applications
72
4
1
1