Abstract
Angiogenesis plays an important role in the treatment of acute myocardial infarction (MI). Formation of micro-vessels has the potential to prevent apoptosis of the ischemic myocardium and to improve cardiac function after MI. Delivery of growth factors or administration of stem/progenitor cells (mainly from bone marrow) are the dominant therapies to induce angiogenesis after MI. Nevertheless, clinical trials have shown that delivery of a single growth factor or single type of cell does not provide sufficient angiogenesis to promote cardiac repair. Circadian rhythms control many physiological and pathological processes in mammals. Many studies show a close relationship between circadian rhythms and MI. Disruption of the circadian rhythms in humans leads to increased incidence of MI. The onset and infarct area of MI are markedly elevated at certain time points. Determining the mechanisms of angiogenesis and vessel maturation in the ischemic heart under the control of circadian rhythms could help in the development of novel and angiogenesis- targeted therapeutics for the treatment of MI.
Keywords: Angiogenesis, circadian rhythms, myocardial infarction, period 2.
Current Pharmaceutical Design
Title:Disruption of Circadian Rhythms and Sleep in Critical Illness: Potential Implications for Angiogenesis After Myocardial Infarction. A Review
Volume: 21 Issue: 24
Author(s): Yuan-Yuan Sun, Zhan-Hui Du and Yu-Xia Zhao
Affiliation:
Keywords: Angiogenesis, circadian rhythms, myocardial infarction, period 2.
Abstract: Angiogenesis plays an important role in the treatment of acute myocardial infarction (MI). Formation of micro-vessels has the potential to prevent apoptosis of the ischemic myocardium and to improve cardiac function after MI. Delivery of growth factors or administration of stem/progenitor cells (mainly from bone marrow) are the dominant therapies to induce angiogenesis after MI. Nevertheless, clinical trials have shown that delivery of a single growth factor or single type of cell does not provide sufficient angiogenesis to promote cardiac repair. Circadian rhythms control many physiological and pathological processes in mammals. Many studies show a close relationship between circadian rhythms and MI. Disruption of the circadian rhythms in humans leads to increased incidence of MI. The onset and infarct area of MI are markedly elevated at certain time points. Determining the mechanisms of angiogenesis and vessel maturation in the ischemic heart under the control of circadian rhythms could help in the development of novel and angiogenesis- targeted therapeutics for the treatment of MI.
Export Options
About this article
Cite this article as:
Sun Yuan-Yuan, Du Zhan-Hui and Zhao Yu-Xia, Disruption of Circadian Rhythms and Sleep in Critical Illness: Potential Implications for Angiogenesis After Myocardial Infarction. A Review, Current Pharmaceutical Design 2015; 21 (24) . https://dx.doi.org/10.2174/1381612821666150706111504
DOI https://dx.doi.org/10.2174/1381612821666150706111504 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Phytoestrogens: Implications in Neurovascular Research
Current Neurovascular Research Pleiotropic Effects of Omega-3 Fatty Acids
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Inflammation as a Therapeutic Target in Acute Ischemic Stroke Treatment
Current Topics in Medicinal Chemistry High Sensitivity Troponin in Cardiovascular Disease. Is There More Than a Marker of Myocardial Death?
Current Topics in Medicinal Chemistry Some Developments Regarding Functional Food Products (Functional Foods)
Current Nutrition & Food Science CD44 - a New Cardiovascular Drug Target or Merely an Innocent Bystander?
Cardiovascular & Hematological Disorders-Drug Targets Biological Activities of Quinoline Derivatives
Mini-Reviews in Medicinal Chemistry “Endothelial Progenitor Cells” as a Therapeutic Strategy in Cardiovascular Disease
Current Vascular Pharmacology Fontan Circulation Might be Associated with Peripartum Cardiomyopathy: A Review of Mechanistic and Clinical Aspects
Current Cardiology Reviews The Role of Endothelial Dysfunction in Aortic Aneurysms
Current Pharmaceutical Design The Role of Inflammatory Response in Stroke Associated Programmed Cell Death
Current Neuropharmacology Cognitive and Cardiovascular Benefits of Docosahexaenoic Acid in Aging and Cognitive Decline
Current Alzheimer Research Juglans regia Seeds have Effects on Platelets and Peripheral Fat Deposition in the Aorta and Heart of C57BL/6J Mice Fed with Normal and High Fat Simple Carbohydrate Diet
Current Nutrition & Food Science Phenolic Compounds as Antioxidants: Carbonic Anhydrase Isoenzymes Inhibitors
Mini-Reviews in Medicinal Chemistry Current Therapeutic Strategies and Future Perspectives for the Prevention of Arterial Thromboembolism: Focus on Atrial Fibrillation
Current Pharmaceutical Design Epidemiology of Diabetes Mellitus in the United Arab Emirates
Current Diabetes Reviews Clinical Impacts in Cardiovascular Molecular Imaging: the Example of Cardiac Sympathetic Imaging in Heart Failure
Current Medical Imaging Experimental Models of Abdominal Aortic Aneurysms: An Overview
Current Pharmaceutical Design Insulin Resistance-Induced Hypertension and a Role of Perivascular CGRPergic Nerves
Current Protein & Peptide Science Female Infertility and Cardiovascular Risk - A Hype or an Underestimated Reality?
Current Pharmaceutical Design