Abstract
Porous microspheres of casein/amorphous calcium phosphate nanocomposite are prepared using casein sodium salt, CaCl2, Na2HPO4•12H2O and Na2HPO4•12H2O in aqueous solution at room temperature. The effects of experimental parameters such as solution pH, casein sodium salt and ageing time on the product are investigated. Porous microspheres of casein/amorphous calcium phosphate nanocomposite are characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric (TG) analysis, and Brunauer-Emmett-Teller (BET) specific surface area and pore size distribution. The as-prepared porous microspheres of casein/amorphous calcium phosphate nanocomposite are favorable for drug loading and release using ibuprofen (IBU), docetaxel (Dtxl) and vitamin B5 (B5) as typical drugs, and show low cytotoxicity in the cytotoxicity test. Thus, porous microspheres of casein/amorphous calcium phosphate nanocomposite have promising applications in various biomedical fields such as drug delivery.
Keywords: Amorphous materials, calcium phosphate, casein, drug delivery, nanocomposite, nanostructures.
Current Nanoscience
Title:Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery
Volume: 12 Issue: 1
Author(s): Guan-Jun Ding, Ying-Jie Zhu, Guo-Feng Cheng, Yin-Jie Ruan, Chao Qi, Bing-Qiang Lu, Feng Chen and Jin Wu
Affiliation:
Keywords: Amorphous materials, calcium phosphate, casein, drug delivery, nanocomposite, nanostructures.
Abstract: Porous microspheres of casein/amorphous calcium phosphate nanocomposite are prepared using casein sodium salt, CaCl2, Na2HPO4•12H2O and Na2HPO4•12H2O in aqueous solution at room temperature. The effects of experimental parameters such as solution pH, casein sodium salt and ageing time on the product are investigated. Porous microspheres of casein/amorphous calcium phosphate nanocomposite are characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric (TG) analysis, and Brunauer-Emmett-Teller (BET) specific surface area and pore size distribution. The as-prepared porous microspheres of casein/amorphous calcium phosphate nanocomposite are favorable for drug loading and release using ibuprofen (IBU), docetaxel (Dtxl) and vitamin B5 (B5) as typical drugs, and show low cytotoxicity in the cytotoxicity test. Thus, porous microspheres of casein/amorphous calcium phosphate nanocomposite have promising applications in various biomedical fields such as drug delivery.
Export Options
About this article
Cite this article as:
Ding Guan-Jun, Zhu Ying-Jie, Cheng Guo-Feng, Ruan Yin-Jie, Qi Chao, Lu Bing-Qiang, Chen Feng and Wu Jin, Porous Microspheres of Casein/Amorphous Calcium Phosphate Nanocomposite: Room Temperature Synthesis and Application in Drug Delivery, Current Nanoscience 2016; 12 (1) . https://dx.doi.org/10.2174/1573413711666150730204449
DOI https://dx.doi.org/10.2174/1573413711666150730204449 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
TNF-α and Ghrelin: Opposite Effects on Immune System, Metabolism and Mental Health
Protein & Peptide Letters Phosphodiesterase 5 Inhibitors in the Treatment of Erectile Dysfunction
Current Pharmaceutical Design Phospholipase A2 Isoforms as Novel Targets for Prevention and Treatment of Inflammatory and Oncologic Diseases
Current Drug Targets Potential Anticancer Properties of Bisphosphonates: Insights From Preclinical Studies
Anti-Cancer Agents in Medicinal Chemistry Target Driven Preclinical Screening for New Antimitotic Chemotherapy Agents
Current Topics in Medicinal Chemistry Hepatocyte Growth Factor Signaling in Cancer Metastasis
Current Signal Transduction Therapy Involvement of Cysteine Proteases in Cancer
Current Medicinal Chemistry A Timely Review of State-of-the-Art Chronopharmaceuticals Synchronized with Biological Rhythms
Current Drug Delivery Editorial (Thematic Issue: Clinical Advances in Immuno-oncology – Progress Towards Selective Cure)
Current Molecular Pharmacology Molecular Modelling, Design, Synthesis and Biochemical Evaluation of a Range of Non-Steroidal Thiosemicarbazone-Based Inhibitors of Estrone Sulfatase (ES) - A Potential Insight into the Action of a Range of Allosteric Inhibitors of ES
Letters in Drug Design & Discovery Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review
Anti-Cancer Agents in Medicinal Chemistry Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder
Current Pharmaceutical Design Inflammation and Mood Disorders: Proinflammatory Cytokines and the Pathogenesis of Depression
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Genetic Variation in SLCO2B1 is Associated with Serum Levels of Testosterone and its Metabolites Prior to and Two Days after Testosterone Administration
Current Pharmacogenomics and Personalized Medicine Editorial [Hot Topic Ion Fluxes and Cancer (Guest Editors: Luca Munaron and Annarosa Arcangeli)]
Recent Patents on Anti-Cancer Drug Discovery Molecular Chaperone Activity and Biological Regulatory Actions of the TPR-Domain Immunophilins FKBP51 and FKBP52
Current Protein & Peptide Science Osteoporotic Fracture Healing: Potential Use of Medicinal Plants from the Tropics
Current Drug Targets New Perspective Therapy of Breast Cancer Based on Selective Dopamine Receptor D2 Agonist and Antagonist Effects on MCF-7 Cell Line
Recent Patents on Anti-Cancer Drug Discovery DNA-Binding Properties of Poly(ADP-Ribose) Polymerase: A Target for Anti-Cancer Therapy
Current Drug Targets Arginyl Aminopeptidase-Like 1 (RNPEPL1) Is an Alternatively Processed Aminopeptidase with Specificity for Methionine, Glutamine, and Citrulline Residues
Protein & Peptide Letters