Abstract
Dry powder inhalers are one of the most popular devices for delivering medication directly to the lungs of patients. Both for local action and when using the lungs as a portal of entry into the systemic circulation. Dry powder inhalers rely on the patient’s inspiratory effort to supply the energy for the device to effectively deliver medication. In this respect they are limited by the airway pressures that a patient can generate with their respiratory muscles. In this review we focus on a simple model outlining the variables influencing respiratory pressure and review the literature on inspiratory flow rates in patients with respiratory disease. The main determinants of the capability to generate the pressure necessary to effectively use a dry powder inhaler are shown to be age and gender, not disease or disease severity.
Keywords: Dry powder inhalers, device resistance, inspiratory flow rates, inspiratory pressures, asthma, cystic fibrosis, COPD.
Current Pharmaceutical Design
Title:The Role of Inspiratory Pressures in Determining the Flow Rates Though Dry Powder Inhalers; A Review
Volume: 21 Issue: 27
Author(s): Andrew R. Clark
Affiliation:
Keywords: Dry powder inhalers, device resistance, inspiratory flow rates, inspiratory pressures, asthma, cystic fibrosis, COPD.
Abstract: Dry powder inhalers are one of the most popular devices for delivering medication directly to the lungs of patients. Both for local action and when using the lungs as a portal of entry into the systemic circulation. Dry powder inhalers rely on the patient’s inspiratory effort to supply the energy for the device to effectively deliver medication. In this respect they are limited by the airway pressures that a patient can generate with their respiratory muscles. In this review we focus on a simple model outlining the variables influencing respiratory pressure and review the literature on inspiratory flow rates in patients with respiratory disease. The main determinants of the capability to generate the pressure necessary to effectively use a dry powder inhaler are shown to be age and gender, not disease or disease severity.
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Cite this article as:
Clark R. Andrew, The Role of Inspiratory Pressures in Determining the Flow Rates Though Dry Powder Inhalers; A Review, Current Pharmaceutical Design 2015; 21 (27) . https://dx.doi.org/10.2174/1381612821666150820105800
DOI https://dx.doi.org/10.2174/1381612821666150820105800 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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