Abstract
In recent decades the need for new chiral compounds with high enantiomeric excesses has been rapidly emerging. Among the various methods used to achieve chiral compounds, one can highlight the enzymatic kinetic resolution of racemic esters, alcohols and amines and as the most versatile enzymatic methodology used in organic routes. Enzymes are used in biocatalytic routes to obtain enriched and enantiomerically pure compounds. The most remarkable biocatalysts for these processes are lipases, which have the capability of being used in organic media. Thus, the main purpose of this article was to present a review about studies conducted in Brazil involving the kinetic resolution of racemic compounds using lipases, also including unusual substrates containing heteroatoms, such as boron, silicon, selenium, tellurium and sulfur.
Keywords: Biocatalysis, Lipases, Candida antarctica, Immobilization, Kinetic Resolution.
Current Organic Synthesis
Title:Contributions on Kinetic Resolution by Lipases on the Development of Organic Synthesis in Brazil
Volume: 12 Issue: 6
Author(s): Leandro H. Andrade, Bruno A. Sousa, Irlon M. Ferreira and André L. M. Porto
Affiliation:
Keywords: Biocatalysis, Lipases, Candida antarctica, Immobilization, Kinetic Resolution.
Abstract: In recent decades the need for new chiral compounds with high enantiomeric excesses has been rapidly emerging. Among the various methods used to achieve chiral compounds, one can highlight the enzymatic kinetic resolution of racemic esters, alcohols and amines and as the most versatile enzymatic methodology used in organic routes. Enzymes are used in biocatalytic routes to obtain enriched and enantiomerically pure compounds. The most remarkable biocatalysts for these processes are lipases, which have the capability of being used in organic media. Thus, the main purpose of this article was to present a review about studies conducted in Brazil involving the kinetic resolution of racemic compounds using lipases, also including unusual substrates containing heteroatoms, such as boron, silicon, selenium, tellurium and sulfur.
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Cite this article as:
Andrade H. Leandro, Sousa A. Bruno, Ferreira M. Irlon and Porto L. M. André, Contributions on Kinetic Resolution by Lipases on the Development of Organic Synthesis in Brazil, Current Organic Synthesis 2015; 12 (6) . https://dx.doi.org/10.2174/157017941206150828103404
DOI https://dx.doi.org/10.2174/157017941206150828103404 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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