Abstract
Colon targeted liposomal systems (CTLS) for the delivery of bioactives have been well addressed in therapeutic manifestations of colonic ailments. Number of approaches using various drug delivery systems for colon targeting has been worked out but CTLS are first time being lime lighted in this review. Although liposomes are not supposed to be suitable for colon targeting via oral route this review explicitly provides advances of CTLS using exploitable ligands such as peptides or proteins (e.g. RGD, NGR, fibronectin mimetic peptide, and transferrin), Sialyl Lewis X (SLX), low molecular weight ligand like folate, monoclonal antibodies, endostatin gene and sulfatide etc. Moreover, it is bringing forth the diagnostic (or imaging) potential of CTLS using 188Re, 99mTc, and 111In, etc. This review presents nanotechnology based advances for liposome researchers engaged in design and development of colon targeted liposomes for theranostic exploration.
Keywords: Liposomes, colon, targeting, therapeutic, diagnostic, radiolabel.
Current Molecular Medicine
Title:Colon Targeted Liposomal Systems (CTLS): Theranostic Potential
Volume: 15 Issue: 7
Author(s): A. Jain and S.K. Jain
Affiliation:
Keywords: Liposomes, colon, targeting, therapeutic, diagnostic, radiolabel.
Abstract: Colon targeted liposomal systems (CTLS) for the delivery of bioactives have been well addressed in therapeutic manifestations of colonic ailments. Number of approaches using various drug delivery systems for colon targeting has been worked out but CTLS are first time being lime lighted in this review. Although liposomes are not supposed to be suitable for colon targeting via oral route this review explicitly provides advances of CTLS using exploitable ligands such as peptides or proteins (e.g. RGD, NGR, fibronectin mimetic peptide, and transferrin), Sialyl Lewis X (SLX), low molecular weight ligand like folate, monoclonal antibodies, endostatin gene and sulfatide etc. Moreover, it is bringing forth the diagnostic (or imaging) potential of CTLS using 188Re, 99mTc, and 111In, etc. This review presents nanotechnology based advances for liposome researchers engaged in design and development of colon targeted liposomes for theranostic exploration.
Export Options
About this article
Cite this article as:
Jain A. and Jain S.K., Colon Targeted Liposomal Systems (CTLS): Theranostic Potential, Current Molecular Medicine 2015; 15 (7) . https://dx.doi.org/10.2174/1566524015666150831131320
DOI https://dx.doi.org/10.2174/1566524015666150831131320 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hypothetical Link Between Infertility and Genetically Modified Food
Recent Patents on Food, Nutrition & Agriculture Chondroitin Sulphate for the Treatment of Osteoarthritis
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents APO2L/TRAIL: New Insights in the Treatment of Autoimmune Disorders
Recent Patents on Inflammation & Allergy Drug Discovery 25-hydroxyvitamin D Correlation with Prolactin Levels and Adenoma Size in Female Patients with Newly Diagnosed Prolactin Secreting Adenoma
Endocrine, Metabolic & Immune Disorders - Drug Targets Regulation of βAPP and PrPc Cleavage by α-Secretase: Mechanistic and Therapeutic Perspectives
Current Alzheimer Research Seocalcitol (EB 1089) A Vitamin D Analogue of Anti-cancer Potential. Background, Design, Synthesis, Pre-clinical and Clinical Evaluation
Current Pharmaceutical Design Commercial Opportunities and Ethical Pitfalls in Personalized Medicine: A Myriad of Reasons to Revisit the Myriad Genetics Saga
Current Pharmacogenomics and Personalized Medicine The NK-1 Receptor: A New Target in Cancer Therapy
Current Drug Targets Sulfur Containing Acridine Derivatives in Preclinical Studies with Cancer Cell Lines
Current Medicinal Chemistry Systemic Delivery and Quantification of Unformulated Interfering RNAs In Vivo
Current Topics in Medicinal Chemistry Pathophysiology and Pharmacological Targeting of Tumor-Induced Bone Disease: Current Status and Emerging Therapeutic Interventions
Current Medicinal Chemistry Innate Immune System Modulation During Aging: Contributions of Macrophages and Dendritic Cells
Current Immunology Reviews (Discontinued) Editorial [Hot topic: Recent Progress in Cancer Therapeutics (Guest Editor: Kurt S. Zaenker)]
Current Molecular Medicine The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model
CNS & Neurological Disorders - Drug Targets Therapeutic Gene Products Delivery by Neuron Stem Cells
Current Pharmaceutical Biotechnology Novel Anti-Prostate Cancer Curcumin Analogues That Enhance Androgen Receptor Degradation Activity
Anti-Cancer Agents in Medicinal Chemistry Radiosensitizing Effect of Electrochemotherapy: A Systematic Review of Protocols and Efficiency
Current Drug Targets Synthesis and Antitumoral Evaluation of Benzyl (1S)-2-[2-(monosubstituted-benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate
Letters in Drug Design & Discovery Strategies for the Biological Evaluation of Gold Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Challenges in Oral Delivery: Role of P-gp Efflux Pump
Current Drug Therapy