Abstract
major trend in fine chemicals and pharmaceuticals is the synthesis of molecules with increased complexity. This trend translates the aim of organic syntheses to conditions in which high degrees of chemo-, regioand stereoselectivity can be provided. In this context, the chemoselective hydrogenation of one functional group in the presence of other reactive groups is a frequently encountered problem in fine chemicals manufacture. This study provides a critical analysis including elegant examples of reactions in which high chemo- and diastereoselectivities were achieved in the hydrogenation of a C=O group in the presence of C=C double bond. A particular emphasis is addressed to the stereoselective C(15) synthesis from Cloprostenol - a PGF2α structural analogue.
Keywords: Prostaglandins, cloprostenol, diastereoselectivity, chiral modifier, hydrogenation, heterogeneous catalysis.
Current Pharmaceutical Design
Title:Heterogeneous Diastereoselective Catalysis - A Powerful Strategy Toward C(15) Stereoselectivity from PGF2α Analogues Structure
Volume: 21 Issue: 38
Author(s): Simona M. Coman and Vasile I. Parvulescu
Affiliation:
Keywords: Prostaglandins, cloprostenol, diastereoselectivity, chiral modifier, hydrogenation, heterogeneous catalysis.
Abstract: major trend in fine chemicals and pharmaceuticals is the synthesis of molecules with increased complexity. This trend translates the aim of organic syntheses to conditions in which high degrees of chemo-, regioand stereoselectivity can be provided. In this context, the chemoselective hydrogenation of one functional group in the presence of other reactive groups is a frequently encountered problem in fine chemicals manufacture. This study provides a critical analysis including elegant examples of reactions in which high chemo- and diastereoselectivities were achieved in the hydrogenation of a C=O group in the presence of C=C double bond. A particular emphasis is addressed to the stereoselective C(15) synthesis from Cloprostenol - a PGF2α structural analogue.
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Cite this article as:
Coman M. Simona and Parvulescu I. Vasile, Heterogeneous Diastereoselective Catalysis - A Powerful Strategy Toward C(15) Stereoselectivity from PGF2α Analogues Structure, Current Pharmaceutical Design 2015; 21 (38) . https://dx.doi.org/10.2174/1381612821666151002113246
DOI https://dx.doi.org/10.2174/1381612821666151002113246 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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