Abstract
This review is aimed at providing an overview of the up-to-now published literature on resorc[4]arene macrocycles exploited as artificial receptors for the molecular recognition of some classes of natural products. A concise illustration of the main synthetic strategies developed to afford the resorc[4]arene scaffold is followed by a report on the principles of the gas-phase investigation of recognition phenomena by mass spectrometry (MS). Emphasis is placed on gas-phase studies of diastereoisomeric complexes generated inside a Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer by resorc[4]arene receptors towards a series of natural products, namely amino acids, amphetamine, ethanolamine neurotransmitters, dipeptides, vinca alkaloids and nucleosides. The literature outcomes discussed here, taken largely from our own revisited work, have been completed by references to other studies, in order to draw a broader picture of this rapidly evolving field of research.
Keywords: Molecular recognition, resorcarenes, artificial receptors, gas-phase investigation, mass spectrometry, natural products, host-guest complexes.
Current Pharmaceutical Design
Title:Molecular Recognition of Natural Products by Resorc[4]arene Receptors
Volume: 22 Issue: 12
Author(s): Ilaria D`Acquarica, Francesca Ghirga, Deborah Quaglio, Antonella Cerreto, Cinzia Ingallina, Andrea Tafi and Bruno Botta
Affiliation:
Keywords: Molecular recognition, resorcarenes, artificial receptors, gas-phase investigation, mass spectrometry, natural products, host-guest complexes.
Abstract: This review is aimed at providing an overview of the up-to-now published literature on resorc[4]arene macrocycles exploited as artificial receptors for the molecular recognition of some classes of natural products. A concise illustration of the main synthetic strategies developed to afford the resorc[4]arene scaffold is followed by a report on the principles of the gas-phase investigation of recognition phenomena by mass spectrometry (MS). Emphasis is placed on gas-phase studies of diastereoisomeric complexes generated inside a Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometer by resorc[4]arene receptors towards a series of natural products, namely amino acids, amphetamine, ethanolamine neurotransmitters, dipeptides, vinca alkaloids and nucleosides. The literature outcomes discussed here, taken largely from our own revisited work, have been completed by references to other studies, in order to draw a broader picture of this rapidly evolving field of research.
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D`Acquarica Ilaria, Ghirga Francesca, Quaglio Deborah, Cerreto Antonella, Ingallina Cinzia, Tafi Andrea and Botta Bruno, Molecular Recognition of Natural Products by Resorc[4]arene Receptors, Current Pharmaceutical Design 2016; 22 (12) . https://dx.doi.org/10.2174/1381612822666151211094712
DOI https://dx.doi.org/10.2174/1381612822666151211094712 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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