Abstract
Chromatin remodeling complexes (chromatin remodelers) have been demonstrated as essential and powerful regulators for critical DNA-templated cellular processes, such as DNA replication, recombination, gene transcription/repression, and DNA damage repair. These molecular and genetic processes are important for a wide spectrum of cellular functions including, cell cycle, death, differentiation, pluripotency, and genome integrity. Not surprisingly, dysfunctions of chromatin remodeling proteins are observed in human developmental disorders and diseases. Specifically for human malignancies, genomic sequence analyses show that mutations and other genetic alternations of chromatin remodelers exist in almost all human tumor types. Using human cancer cell lines, xenograft models and genetically engineered mouse models, functions of chromatin remodelers in human cancers have been studied extensively in the last 10-15 years. In this review, we summarize the functional and mechanistic studies of chromatin remodelers in the initiation, progression and metastasis of human cancers.
Keywords: Chromatin, cancer, chromatin remodeling, chromatin remodeling protein.
Current Protein & Peptide Science
Title:The Roles of Chromatin Remodeling Proteins in Cancer
Volume: 17 Issue: 5
Author(s): Chun Zhang, Jie Lu and Pingyu Zhang
Affiliation:
Keywords: Chromatin, cancer, chromatin remodeling, chromatin remodeling protein.
Abstract: Chromatin remodeling complexes (chromatin remodelers) have been demonstrated as essential and powerful regulators for critical DNA-templated cellular processes, such as DNA replication, recombination, gene transcription/repression, and DNA damage repair. These molecular and genetic processes are important for a wide spectrum of cellular functions including, cell cycle, death, differentiation, pluripotency, and genome integrity. Not surprisingly, dysfunctions of chromatin remodeling proteins are observed in human developmental disorders and diseases. Specifically for human malignancies, genomic sequence analyses show that mutations and other genetic alternations of chromatin remodelers exist in almost all human tumor types. Using human cancer cell lines, xenograft models and genetically engineered mouse models, functions of chromatin remodelers in human cancers have been studied extensively in the last 10-15 years. In this review, we summarize the functional and mechanistic studies of chromatin remodelers in the initiation, progression and metastasis of human cancers.
Export Options
About this article
Cite this article as:
Zhang Chun, Lu Jie and Zhang Pingyu, The Roles of Chromatin Remodeling Proteins in Cancer, Current Protein & Peptide Science 2016; 17 (5) . https://dx.doi.org/10.2174/1389203717666160122120713
DOI https://dx.doi.org/10.2174/1389203717666160122120713 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cancer-Associated Carbonic Anhydrases and Their Inhibition
Current Pharmaceutical Design Asialoglycoprotein Receptor-Targeted Radiopharmaceuticals for Measurement of Liver Function
Current Medicinal Chemistry Emerging Role of ImmunoPET in Receptor Targeted Cancer Therapy
Current Drug Delivery Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Target Driven Preclinical Screening for New Antimitotic Chemotherapy Agents
Current Topics in Medicinal Chemistry Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability
Anti-Cancer Agents in Medicinal Chemistry Editorial Review (Thematic Issue: An Update on Central Sensitivity Syndromes and the Issues of Nosology and Psychobiology)
Current Rheumatology Reviews Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activities
Current Pharmaceutical Design Quality of Life Assessments in Colorectal Cancer Surgery. A Review
Current Cancer Therapy Reviews Biomarkers of Protein Oxidation in Human Disease
Current Molecular Medicine A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin
Current Drug Targets Male Pelvic Pain: Beyond Urology and Chronic Prostatitis
Current Rheumatology Reviews The Thyroid Gland: A Crossroad in Inflammation-Induced Carcinoma? An Ongoing Debate with New Therapeutic Potential.
Current Medicinal Chemistry Current Evidence from Phase III Clinical Trials of Selenium Supplementation in Critically Ill Patients: Why Should We Bother?
Mini-Reviews in Medicinal Chemistry Cruciferous Plants: Phytochemical Toxicity Versus Cancer Chemoprotection
Mini-Reviews in Medicinal Chemistry FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data
Combinatorial Chemistry & High Throughput Screening Modulation of Doxorubicin Mediated Growth Inhibition of Hepatocellular Carcinoma Cells by Platelet Lysates
Anti-Cancer Agents in Medicinal Chemistry The Management of Phosphodiesterase-5 (PDE5) Inhibitor Failure
Current Vascular Pharmacology Pharmacotherapy for the Metabolic Syndrome
Current Vascular Pharmacology Anti Cancer Activity on Graviola, an Exciting Medicinal Plant Extract vs Various Cancer Cell Lines and a Detailed Computational Study on its Potent Anti-Cancerous Leads
Current Topics in Medicinal Chemistry