Abstract
Assessment of toxicity is an important component of the drug discovery process. Cellbased assays are a popular choice for assessing cytotoxicity. However, these assays are complex because of the wide variety of formats and methods that are available, lack of standardization, confusing terminology and the inherent variability of biological systems and measurement. This review is intended as a guide on how to take these factors into account when planning, conducting and/or interpreting cell based toxicity assays.
Keywords: Cytotoxicity, cytotoxicity screening, viability assays, apoptosis, cell-based assays, toxicity.
Medicinal Chemistry
Title:Cell-based Assays for Assessing Toxicity: A Basic Guide
Volume: 13 Issue: 1
Author(s): Raveen Parboosing, Gugulethu Mzobe, Louis Chonco and Indres Moodley
Affiliation:
Keywords: Cytotoxicity, cytotoxicity screening, viability assays, apoptosis, cell-based assays, toxicity.
Abstract: Assessment of toxicity is an important component of the drug discovery process. Cellbased assays are a popular choice for assessing cytotoxicity. However, these assays are complex because of the wide variety of formats and methods that are available, lack of standardization, confusing terminology and the inherent variability of biological systems and measurement. This review is intended as a guide on how to take these factors into account when planning, conducting and/or interpreting cell based toxicity assays.
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Cite this article as:
Parboosing Raveen, Mzobe Gugulethu, Chonco Louis and Moodley Indres, Cell-based Assays for Assessing Toxicity: A Basic Guide, Medicinal Chemistry 2017; 13 (1) . https://dx.doi.org/10.2174/1573406412666160229150803
DOI https://dx.doi.org/10.2174/1573406412666160229150803 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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