Abstract
Puerarin is an isoflavonoid extracted from the roots of Pueraria lobata in the Pueraria thomsonii family. Puerarin displays a broad range of pharmacological activities and has been widely used in clinics. However, puerarin’s low solubility and permeability result in poor gastrointestinal absorption and low bioavailability. Simply increasing the dose does not effectively increase bioavailability and might lead to toxicity and side effects. Considerable progress has been achieved in the recent years on puerarin structural biotransformation using microorganisms and free enzymes. Increasingly numerous new puerarin derivatives with high solubility and bioactivity have been developed. This paper reviews recent progress in the biotransformation of puerarin.
Keywords: Biotransformation, Deglycosylation, Glycosylation, Hydroxylation, Puerarin, Research progress.
Mini-Reviews in Medicinal Chemistry
Title:Recent Advances in Methods of Puerarin Biotransformation
Volume: 16 Issue: 17
Author(s): Guiyou Liu, Zhonghua Liu and Sheng Yuan
Affiliation:
Keywords: Biotransformation, Deglycosylation, Glycosylation, Hydroxylation, Puerarin, Research progress.
Abstract: Puerarin is an isoflavonoid extracted from the roots of Pueraria lobata in the Pueraria thomsonii family. Puerarin displays a broad range of pharmacological activities and has been widely used in clinics. However, puerarin’s low solubility and permeability result in poor gastrointestinal absorption and low bioavailability. Simply increasing the dose does not effectively increase bioavailability and might lead to toxicity and side effects. Considerable progress has been achieved in the recent years on puerarin structural biotransformation using microorganisms and free enzymes. Increasingly numerous new puerarin derivatives with high solubility and bioactivity have been developed. This paper reviews recent progress in the biotransformation of puerarin.
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Cite this article as:
Liu Guiyou, Liu Zhonghua and Yuan Sheng, Recent Advances in Methods of Puerarin Biotransformation, Mini-Reviews in Medicinal Chemistry 2016; 16 (17) . https://dx.doi.org/10.2174/1389557516666160505114456
DOI https://dx.doi.org/10.2174/1389557516666160505114456 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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