Abstract
Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.
Keywords: Matrine derivatives, Biological activities, Structural modifications, Mechanism of action, Structure-activity relationship, Sophora flavescens.
Current Topics in Medicinal Chemistry
Title:Matrine: Bioactivities and Structural Modifications
Volume: 16 Issue: 28
Author(s): Jiulin Huang and Hui Xu
Affiliation:
Keywords: Matrine derivatives, Biological activities, Structural modifications, Mechanism of action, Structure-activity relationship, Sophora flavescens.
Abstract: Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.
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Cite this article as:
Huang Jiulin and Xu Hui, Matrine: Bioactivities and Structural Modifications, Current Topics in Medicinal Chemistry 2016; 16 (28) . https://dx.doi.org/10.2174/1568026616666160506131012
DOI https://dx.doi.org/10.2174/1568026616666160506131012 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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