Abstract
Natural sulphurated amino acids are cysteine and methionine. Their importance in biological processes is largely known. Cysteine, plays a key role due to the thiol group, which represents a nucleophilic and easily oxidizable function. Synthetic methodologies to obtain Cysteine-, Methionineand Seleno-Cysteine-Proline chimeras are strongly desirable and particularly appealing in the field of organic chemistry.
Keywords: Cysteine, methionine, seleno-cysteine proline chimeras, peptidomimetic design, χ-Space, chemical ligation.
Current Bioactive Compounds
Title:Cysteine-, Methionine- and Seleno-Cysteine-Proline Chimeras: Synthesis and Their Use in Peptidomimetics Design
Volume: 12 Issue: 3
Author(s): Azzurra Stefanucci, Roberto Costante, Giorgia Macedonio, Szabolcs Dvoracsko and Adriano Mollica
Affiliation:
Keywords: Cysteine, methionine, seleno-cysteine proline chimeras, peptidomimetic design, χ-Space, chemical ligation.
Abstract: Natural sulphurated amino acids are cysteine and methionine. Their importance in biological processes is largely known. Cysteine, plays a key role due to the thiol group, which represents a nucleophilic and easily oxidizable function. Synthetic methodologies to obtain Cysteine-, Methionineand Seleno-Cysteine-Proline chimeras are strongly desirable and particularly appealing in the field of organic chemistry.
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Cite this article as:
Stefanucci Azzurra, Costante Roberto, Macedonio Giorgia, Dvoracsko Szabolcs and Mollica Adriano, Cysteine-, Methionine- and Seleno-Cysteine-Proline Chimeras: Synthesis and Their Use in Peptidomimetics Design, Current Bioactive Compounds 2016; 12 (3) . https://dx.doi.org/10.2174/1573407212666160511162915
DOI https://dx.doi.org/10.2174/1573407212666160511162915 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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