Abstract
Background: Recent findings suggest that dopaminergic abnormalities found in psychotic disorders may be secondary to nitric oxide dysfunctions. Nitric oxide seems to influence glutamatergic and dopaminergic neurotransmission, both of which have been associated with psychosis. Objective: To search and review published works which examined the influence of nitric oxide in psychotic disorders subjects. Method: The research was executed in the on-line collections of Pubmed and ISI Web of Science. The key aspects utilized were “Psychotic Disorders AND Nitric Oxide”, “Psychosis AND Nitric Oxide”,“Schizotypal Personality Disorder AND Nitric Oxide”, “Delusional Disorder AND Nitric Oxide”, “Brief Psychotic Disorder AND Nitric Oxide”, “Schizophreniform Disorder AND Nitric Oxide”, “Schizoaffective Disorder AND Nitric Oxide”, and “Schizophrenia AND Nitric Oxide”. Empirical works utilizing human subjects, published in the last 10 years, in English language were included. Results: Initially, the search yielded a total of 95 studies. Then, 39 were elected according to the inclusion requirements. The selected articles were divided into five groups: biochemical studies (n=15; 38.5%), genetic studies (n=11; 28.2%), postmortem studies (n=6; 15.4%), clinical trials (n=6; 15.4%), and case reports (n=1; 2.5%). The studies evaluated only schizophrenic or schizoaffective disorder subjects. The great majority of them found evidence of nitric oxide dysfunctions in psychosis. Conclusion: The results of the review strengthen the idea that nitric oxide has a key participation in psychotic disorders and deserves deeper investigation as a target for future pharmacological intervention.
Keywords: Nitric Oxide, Nitric Oxide System, Psychosis, Psychotic Disorders, Schizophrenia, Schizoaffective Disorder.
Current Medicinal Chemistry
Title:Nitric Oxide’s Involvement in the Spectrum of Psychotic Disorders
Volume: 23 Issue: 24
Author(s): João Paulo Maia-de-Oliveira, Ludmyla Kandratavicius, Emerson Arcoverde Nunes, João Paulo Machado-de-Sousa, Jaime E. Hallak and Serdar Murat Dursun
Affiliation:
Keywords: Nitric Oxide, Nitric Oxide System, Psychosis, Psychotic Disorders, Schizophrenia, Schizoaffective Disorder.
Abstract: Background: Recent findings suggest that dopaminergic abnormalities found in psychotic disorders may be secondary to nitric oxide dysfunctions. Nitric oxide seems to influence glutamatergic and dopaminergic neurotransmission, both of which have been associated with psychosis. Objective: To search and review published works which examined the influence of nitric oxide in psychotic disorders subjects. Method: The research was executed in the on-line collections of Pubmed and ISI Web of Science. The key aspects utilized were “Psychotic Disorders AND Nitric Oxide”, “Psychosis AND Nitric Oxide”,“Schizotypal Personality Disorder AND Nitric Oxide”, “Delusional Disorder AND Nitric Oxide”, “Brief Psychotic Disorder AND Nitric Oxide”, “Schizophreniform Disorder AND Nitric Oxide”, “Schizoaffective Disorder AND Nitric Oxide”, and “Schizophrenia AND Nitric Oxide”. Empirical works utilizing human subjects, published in the last 10 years, in English language were included. Results: Initially, the search yielded a total of 95 studies. Then, 39 were elected according to the inclusion requirements. The selected articles were divided into five groups: biochemical studies (n=15; 38.5%), genetic studies (n=11; 28.2%), postmortem studies (n=6; 15.4%), clinical trials (n=6; 15.4%), and case reports (n=1; 2.5%). The studies evaluated only schizophrenic or schizoaffective disorder subjects. The great majority of them found evidence of nitric oxide dysfunctions in psychosis. Conclusion: The results of the review strengthen the idea that nitric oxide has a key participation in psychotic disorders and deserves deeper investigation as a target for future pharmacological intervention.
Export Options
About this article
Cite this article as:
Maia-de-Oliveira Paulo João, Kandratavicius Ludmyla, Nunes Arcoverde Emerson, Machado-de-Sousa Paulo João, Hallak E. Jaime and Dursun Murat Serdar, Nitric Oxide’s Involvement in the Spectrum of Psychotic Disorders, Current Medicinal Chemistry 2016; 23 (24) . https://dx.doi.org/10.2174/0929867323666160721144549
DOI https://dx.doi.org/10.2174/0929867323666160721144549 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Updated Role of Oxidative Stress in Subarachnoid Hemorrhage
Current Drug Delivery Exercise Prevents Cognitive Function Decline and Demyelination in the White Matter of APP/PS1 Transgenic AD Mice
Current Alzheimer Research Role of Cdk5 in Amyloid-beta Pathology of Alzheimer’s Disease
Current Alzheimer Research Delineating Somatostatins Neuronal Actions
Current Drug Targets - CNS & Neurological Disorders Hypoxia, Lead Toxicities and Oxidative Stress: Cell Signaling, Molecular Interactions and Antioxidant (Vitamin C) Defense
Current Signal Transduction Therapy Design and Synthesis of Dopaminergic Agonists
Current Medicinal Chemistry Editorial [Hot Topic: Anti-Amyloidogenic/Protein-Misfolding Therapies in Amyloidosis and Other Protein-Misfolding Disorders (Executive Editor: Masahito Yamada)]
Current Pharmaceutical Design Neuropsychological Consequences of HIV and Substance Abuse: A Literature Review and Implications for Treatment and Future Research
Current Drug Abuse Reviews Neurobiology and Genetics of Behavioural Syndromes of Alzheimers Disease
Current Alzheimer Research Molecular Imaging of Neuropsychiatry and Boron Neutron Capture Therapy in Neuro-oncology
Current Molecular Imaging (Discontinued) Role of Vitamins in Human Health and Nutrition: Sources and Morbidity
Current Nutrition & Food Science Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Platelet Resistance to Antiplatelet Drugs
Recent Patents on Cardiovascular Drug Discovery Neuron-Specific Mitochondrial DNA Deletion Levels in Sporadic Alzheimer´s Disease
Current Alzheimer Research ADAM10 as a Therapeutic Target for Cancer and Inflammation
Current Pharmaceutical Design Vitamin D Levels in Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome
Current Vascular Pharmacology Differentiating Normal from Pathological Brain Ageing Using Standard Neuropsychological Tests
Current Alzheimer Research Reliability of the Alzheimer’s Disease Assessment Scale (ADAS-Cog) in longitudinal Studies
Current Alzheimer Research Intra and Extracellular Protein Interactions with Tau
Current Alzheimer Research Alpha-1-Antichymotrypsin: A Common Player for Type 2 Diabetes and Alzheimer's Disease
Current Diabetes Reviews