Abstract
Background: The sestrin family includes several conserved stress-induced proteins that contribute to the maintenance of homeostasis, DNA stability and cell viability in response to various types of injuries.
Objective: It is well established that the protective functions of AMP-dependent protein kinase (AMPK) and/or mammalian target of rapamycin (mTOR) are regulated by sestrins. Additionally, it has been revealed that sestrins are able to protect cells from oxidative stress by scavenging reactive oxygen species (ROS). Method: The essential involvement of sestrins in mTORC1 inhibition and ROS scavenging signaling pathways, which modulate metabolism homeostasis and regulate autophagy, indicates that sestrins may serve as a potential agent for cell growth, development, metabolism, and neurodegenerative disorders. However, the potential role of sestrins in stroke has not been discussed and summarized. Results & Conclusion: Based on the current understanding of sestrins, it is believed that sestrins are one of the potential endogenous protective molecules/mechanisms following cerebral stroke, which are associated with neuronal protection, neuroinflammation suppression, and blood brain barrier preservation.Keywords: AMP-dependent protein kinase, mammalian target of rapamycin, reactive oxygen species, redox, Sestrins.
Current Drug Delivery
Title:Sestrins: A New Kid for Stroke Treatment?
Volume: 14 Issue: 6
Author(s): Xudan Shi, Liang Xu, Jay Malagult, Jiping Tang, Min Yan and John H. Zhang*
Affiliation:
- Department of Anesthesiology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA, 92354,United States
Keywords: AMP-dependent protein kinase, mammalian target of rapamycin, reactive oxygen species, redox, Sestrins.
Abstract: Background: The sestrin family includes several conserved stress-induced proteins that contribute to the maintenance of homeostasis, DNA stability and cell viability in response to various types of injuries.
Objective: It is well established that the protective functions of AMP-dependent protein kinase (AMPK) and/or mammalian target of rapamycin (mTOR) are regulated by sestrins. Additionally, it has been revealed that sestrins are able to protect cells from oxidative stress by scavenging reactive oxygen species (ROS). Method: The essential involvement of sestrins in mTORC1 inhibition and ROS scavenging signaling pathways, which modulate metabolism homeostasis and regulate autophagy, indicates that sestrins may serve as a potential agent for cell growth, development, metabolism, and neurodegenerative disorders. However, the potential role of sestrins in stroke has not been discussed and summarized. Results & Conclusion: Based on the current understanding of sestrins, it is believed that sestrins are one of the potential endogenous protective molecules/mechanisms following cerebral stroke, which are associated with neuronal protection, neuroinflammation suppression, and blood brain barrier preservation.Export Options
About this article
Cite this article as:
Shi Xudan, Xu Liang, Malagult Jay, Tang Jiping, Yan Min and Zhang H. John*, Sestrins: A New Kid for Stroke Treatment?, Current Drug Delivery 2017; 14 (6) . https://dx.doi.org/10.2174/1567201814666161111125249
DOI https://dx.doi.org/10.2174/1567201814666161111125249 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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