Abstract
Objective: This review describes the discovery during the last five years of novel compounds with significant antimicrobial activity from marine actinomycetes; descriptions include their origins, relevant structures and antimicrobial activities. These antimicrobial compounds belong to several structural classes including alkaloids, peptides, polyketides, macrolides, glycosides, phenols and others. They further express antimicrobial activity against Gram-positive, Gram-negative and fungal pathogens.
Method: We additionally summarize the present knowledge of marine actinomycetes, as a potential source for producing antibiotics. Significantly, more than 15 kinds of structures, such as xinghaiamine A (12), and arenimycin (82), showed antimicrobial activity against multidrug resistant (MDR) pathogenic strains. Compounds such as mollemycin A (17, IC50 values of 10 - 50 nM ) and glycosylated macrolactins (83 and 84, MIC values of 0.055 - 0.220 μM) showed potent activity and may be considered as candidates with significant potential for antibiotic drug discovery. Three different types of compounds, lajollamycins (8-11), bahamaolides (95 and 96) and glycosylated benzoxazine (102 and 103) showed inhibitory activity against Candida albicans isocitrate lyase (ICL).
Conclusion: As compiled in this review, antimicrobial natural products are frequently found in marine actinomycetes and are an important supply of molecules with great potential for biotechnological applications. Marine actinomycetes, therefore, attracted recent research interest. The opportunities and challenges for exploring marine actinomycetes-derived natural products need to be further elucidated.
Keywords: Natural products, antimicrobial activity, marine actinomycetes, structures, antibiotic, pathogen.
Graphical Abstract
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Small Molecules, Big Impact: Pioneering Approaches in Anti-inflammatory Care
This thematic issue is dedicated to the latest advancements and research breakthroughs in the realm of anti-inflammatory pharmacotherapy. With inflammation playing a critical role in numerous chronic conditions such as cardiovascular diseases, diabetes, and autoimmune disorders, there is an urgent need for more targeted, effective, and safer anti-inflammatory treatments. This ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
66
5
1
1