Abstract
Recently, a number of promising ruthenium complexes have been investigated as anticancer drugs. Ru-arene complexes with [(η6-arene)Ru(X)(Y)(Z)] type, which exhibit a great structural variety, offer much potential in drug design. In this review we provide an overview of the progress in the field of arene ruthenium chemistry. We focus our attention particularly on the molecular structures and the anticancer applications of the Ru-arene complexes. Recent developments in the chemistry of arene ruthenium complexes will provide information for the investigation of novel anticancer organometallic drugs.
Keywords: Anticancer agent, antitumor, cytotoxicity, ruthenium-arene complexes, cell, inorganic compounds.
Mini-Reviews in Medicinal Chemistry
Title:Design of Ru-arene Complexes for Antitumor Drugs
Volume: 18 Issue: 2
Author(s): Wei Su, Yuchun Li and Peiyuan Li*
Affiliation:
- College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530000,China
Keywords: Anticancer agent, antitumor, cytotoxicity, ruthenium-arene complexes, cell, inorganic compounds.
Abstract: Recently, a number of promising ruthenium complexes have been investigated as anticancer drugs. Ru-arene complexes with [(η6-arene)Ru(X)(Y)(Z)] type, which exhibit a great structural variety, offer much potential in drug design. In this review we provide an overview of the progress in the field of arene ruthenium chemistry. We focus our attention particularly on the molecular structures and the anticancer applications of the Ru-arene complexes. Recent developments in the chemistry of arene ruthenium complexes will provide information for the investigation of novel anticancer organometallic drugs.
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Cite this article as:
Su Wei , Li Yuchun and Li Peiyuan*, Design of Ru-arene Complexes for Antitumor Drugs, Mini-Reviews in Medicinal Chemistry 2018; 18 (2) . https://dx.doi.org/10.2174/1389557517666170510113453
DOI https://dx.doi.org/10.2174/1389557517666170510113453 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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