Abstract
Considering the diverse applications and importance of DNA topoisomerases II (TOP II) inhibitors in biological systems, it is vital to understand the fundamental organic chemistry of these inhibitory agents through various synthetic strategies and it is crucial for further developments of the same. Many of the reported TOP II inhibitors are associated with extreme structural complexities and require multi-step synthetic routes providing difficulties towards their preparation and modifications. The present work describes the synthetic protocols for a diverse array of candidates relating to both TOP II poisons and catalytic inhibitors which may be useful for further synthetic developments.
Keywords: Topoisomerase II, etoposide, mitoxantrone, pharmacophoresm, podophyllotoxin, antineoplastic agent.
Mini-Reviews in Organic Chemistry
Title:Synthetic Approaches to Various Class of Topoisomerase II Inhibitors
Volume: 14 Issue: 5
Author(s): Sanal Dev*, Nishad Gabhe, S.R. Dhaneshwar, Monu Joy and Bijo Mathew
Affiliation:
- Department of Pharmaceutical Chemistry, Al Shifa College of Pharmacy, Perintalmanna, Kerala – 679325,India
Keywords: Topoisomerase II, etoposide, mitoxantrone, pharmacophoresm, podophyllotoxin, antineoplastic agent.
Abstract: Considering the diverse applications and importance of DNA topoisomerases II (TOP II) inhibitors in biological systems, it is vital to understand the fundamental organic chemistry of these inhibitory agents through various synthetic strategies and it is crucial for further developments of the same. Many of the reported TOP II inhibitors are associated with extreme structural complexities and require multi-step synthetic routes providing difficulties towards their preparation and modifications. The present work describes the synthetic protocols for a diverse array of candidates relating to both TOP II poisons and catalytic inhibitors which may be useful for further synthetic developments.
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Cite this article as:
Dev Sanal*, Gabhe Nishad , Dhaneshwar S.R. , Joy Monu and Mathew Bijo, Synthetic Approaches to Various Class of Topoisomerase II Inhibitors, Mini-Reviews in Organic Chemistry 2017; 14 (5) . https://dx.doi.org/10.2174/1570193X14666170518130301
DOI https://dx.doi.org/10.2174/1570193X14666170518130301 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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