Abstract
Objective: This review article focuses on the neuroprotective effect of drug-induced hypothermia in cerebrovascular diseases and discusses its related side effects.
Method: A systematic literature search was performed using Pubmed and Embase electronic databases for a retrospective analysis. Results: Experimental studies have shown that drug-induced hypothermia alleviates brain damage and plays a neuroprotective role, thereby reducing mortality and ameliorating neurological deficits. Therefore, drug-induced hypothermia has an important research value and is worth further consideration in the clinical setting. However, drug-induced hypothermia is also associated with side effects, such as ventricular tachycardia, ventricular fibrillation, suppressed immune function, infection, electrolyte imbalance, glucose metabolism disorders, and skeletal muscle tremor. Existing drugs with cooling effects belong to the following categories: (1) dopamine receptor agonists; (2) cannabis; (3) opioid receptors; (4) vanilloid receptors; (5) vasopressins (potent neurotensin receptor agonists); (6) thyroid drugs; (7) adenosine drugs; and (8) purine drugs.Keywords: Drug-induced therapeutic hypothermia, neuroprotection, cerebrovascular diseases, cerebral hemorrhage, cerebral ischemia.
Current Drug Targets
Title:Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases
Volume: 18 Issue: 12
Author(s): Junwei Ma, Yibin Wang, Zhong Wang, Haiying Li, Zhimin Wang*Gang Chen*
Affiliation:
- Suzhou Kowloon Hospital affiliated Shanghai Jiaotong University Medical School, Suzhou, Jiangsu Province,China
- Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006,China
Keywords: Drug-induced therapeutic hypothermia, neuroprotection, cerebrovascular diseases, cerebral hemorrhage, cerebral ischemia.
Abstract: Objective: This review article focuses on the neuroprotective effect of drug-induced hypothermia in cerebrovascular diseases and discusses its related side effects.
Method: A systematic literature search was performed using Pubmed and Embase electronic databases for a retrospective analysis. Results: Experimental studies have shown that drug-induced hypothermia alleviates brain damage and plays a neuroprotective role, thereby reducing mortality and ameliorating neurological deficits. Therefore, drug-induced hypothermia has an important research value and is worth further consideration in the clinical setting. However, drug-induced hypothermia is also associated with side effects, such as ventricular tachycardia, ventricular fibrillation, suppressed immune function, infection, electrolyte imbalance, glucose metabolism disorders, and skeletal muscle tremor. Existing drugs with cooling effects belong to the following categories: (1) dopamine receptor agonists; (2) cannabis; (3) opioid receptors; (4) vanilloid receptors; (5) vasopressins (potent neurotensin receptor agonists); (6) thyroid drugs; (7) adenosine drugs; and (8) purine drugs.Export Options
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Cite this article as:
Ma Junwei , Wang Yibin, Wang Zhong , Li Haiying , Wang Zhimin*, Chen Gang*, Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450118666170607104251
DOI https://dx.doi.org/10.2174/1389450118666170607104251 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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