Abstract
Background: Psoriasis is an autoimmune disease of the skin with lapsing episodes of hyperkeratosis, irritation and inflammation. Numerous methodologies and utilization of different antipsoriatic drugs with various activity methods and routes of administration have been investigated to treat this terrifying sickness. In any case, till date, there is no remedy for psoriasis because of the absence of an ideal carrier for effective and safe delivery of antipsoriatic drugs.
Objective: Among the different methods of medications for psoriasis, in the greater part of patients, topical treatment is most commonly utilized. For topical formulations, utilization of conventional excipients could fill the need just to a restricted degree. With the revelation of more up to date biocompatible and biodegradable materials like phospholipids, and Novel drug delivery technologies like liposomes, solid lipid nanoparticles (SLNs), microemulsions, and nanoemulsions, the possibility to enhance the efficiency and safety of the topical products has expanded to a great extent. Understanding the topical delivery aspects and that of outlining and creating different carrier systems have been enhanced that got further novelty to this approach.
Conclusion: Present review is an attempt to contemplate on psoriasis as far as improved comprehension of the dermal delivery perspectives and at present accessible treatment alternatives, significant preventions in psoriasis treatment, late advancements in the conveyance of different antipsoriatic drugs through novel colloidal drug transporters.
Keywords: Dermal drug delivery, liposomes, microemulsions, nanoemulsion, nanoparticles, phospholipids.
Current Pharmaceutical Design
Title:Novel Topical Nanocarriers for Treatment of Psoriasis: An Overview
Volume: 24 Issue: 33
Author(s): Ankita Dadwal, Neeraj Mishra and Raj K. Narang*
Affiliation:
- Department of Pharmaceutics; I.S.F. College of Pharmacy, Ghal Kalan, Ferozpur, G.T road, Moga- 146001, Punjab,India
Keywords: Dermal drug delivery, liposomes, microemulsions, nanoemulsion, nanoparticles, phospholipids.
Abstract: Background: Psoriasis is an autoimmune disease of the skin with lapsing episodes of hyperkeratosis, irritation and inflammation. Numerous methodologies and utilization of different antipsoriatic drugs with various activity methods and routes of administration have been investigated to treat this terrifying sickness. In any case, till date, there is no remedy for psoriasis because of the absence of an ideal carrier for effective and safe delivery of antipsoriatic drugs.
Objective: Among the different methods of medications for psoriasis, in the greater part of patients, topical treatment is most commonly utilized. For topical formulations, utilization of conventional excipients could fill the need just to a restricted degree. With the revelation of more up to date biocompatible and biodegradable materials like phospholipids, and Novel drug delivery technologies like liposomes, solid lipid nanoparticles (SLNs), microemulsions, and nanoemulsions, the possibility to enhance the efficiency and safety of the topical products has expanded to a great extent. Understanding the topical delivery aspects and that of outlining and creating different carrier systems have been enhanced that got further novelty to this approach.
Conclusion: Present review is an attempt to contemplate on psoriasis as far as improved comprehension of the dermal delivery perspectives and at present accessible treatment alternatives, significant preventions in psoriasis treatment, late advancements in the conveyance of different antipsoriatic drugs through novel colloidal drug transporters.
Export Options
About this article
Cite this article as:
Dadwal Ankita , Mishra Neeraj and Narang K. Raj *, Novel Topical Nanocarriers for Treatment of Psoriasis: An Overview, Current Pharmaceutical Design 2018; 24 (33) . https://dx.doi.org/10.2174/1381612824666181102151507
DOI https://dx.doi.org/10.2174/1381612824666181102151507 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Heterocyclic Analogues as Kinase Inhibitors: A Focus Review
Current Topics in Medicinal Chemistry The Role of T-Type Calcium Channels in Peripheral and Central Pain Processing
CNS & Neurological Disorders - Drug Targets Olefin Metathesis Route to Antiviral Nucleosides
Current Topics in Medicinal Chemistry Targeted Anti-leukemic Therapy as Disease-stabilizing Treatment for Acute Myeloid Leukemia Relapse after Allogeneic Stem Cell Transplantation: Will it be Possible to Combine these Strategies with Retransplantation or Donor Lymphocyte Infusions?
Current Cancer Drug Targets Neurovascular Matrix Metalloproteinases and the Blood-Brain Barrier
Current Pharmaceutical Design The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury
Current Pharmaceutical Design The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown
Current Medicinal Chemistry Thiazolidine: A Potent Candidate for Central Nervous System Diseases
Central Nervous System Agents in Medicinal Chemistry Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells
Current Drug Targets The Role of MIF in Hepatic Function, Oxidative Stress, and Inflammation in Thioacetamide-induced Liver Injury in Mice: Protective Effects of Betaine
Current Medicinal Chemistry Mechanisms and Therapeutic Implications of Asthma Circadian Rhythm
Current Respiratory Medicine Reviews Curcumin Targets Circulating Cancer Stem Cells by Inhibiting Self-Renewal Efficacy in Non-Small Cell Lung Carcinoma
Anti-Cancer Agents in Medicinal Chemistry The Expanding Role of TNF-Receptor Super Family Member CD40 (tnfrsf5) in Autoimmune Disease: Focus on Th40 Cells
Current Immunology Reviews (Discontinued) Structure and Function of Water Molecules Buried in the Protein Core
Current Protein & Peptide Science Current Applications of Biopolymer-based Scaffolds and Nanofibers as Drug Delivery Systems
Current Pharmaceutical Design Protective Role of Melatonin in Liver Damage
Current Pharmaceutical Design Characterization of Regulatory T-Cells in Multiple Sclerosis Patients Treated with Interferon Beta-1a
CNS & Neurological Disorders - Drug Targets Properties of the Mesenchymal Endometriotic Stem Cell in the Context of the Immune System and Analysis of its Role in Endometriosis
Recent Patents on Regenerative Medicine Flunarizine Dihydrochloride Nanoemulsion for Migraine Nasal Drug Delivery: Fabrication, Characterization and In Vitro Study
Drug Delivery Letters Applications of Animal Models of Infectious Arthritis in Drug Discovery:A focus on Alphaviral Disease
Current Drug Targets