Generic placeholder image

Current Bioinformatics

Editor-in-Chief

ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

Review Article

Research Progress of Exogenous Plant MiRNAs in Cross-Kingdom Regulation

Author(s): Hao Zhang, Mengping Zhan, Haowu Chang, Shizeng Song, Chunhe Zhang and Yuanning Liu*

Volume 14, Issue 3, 2019

Page: [241 - 245] Pages: 5

DOI: 10.2174/1574893613666181113142414

Price: $65

Abstract

Background: Studies have shown that exogenous miRNAs have cross-kingdom regulatory effects on bacteria and viruses, but whether exogenous plant miRNAs are stable in human body or participate in cross-kingdom regulation is still controversial.

Objective: This study aims to propose a new method for the presence and cross-kingdom regulation pathway of exogenous Plant miRNA, which combines biological calculations and biological experiments.

Method: Based on the high-throughput sequencing data of human health tissue, the tissue specificity model of exogenous plant miRNA can be constructed and the absorption characteristics will be excavated and analyzed. Then screening the exogenous Plant miRNA based on the crosskingdom regulation model of plant-human miRNA, and isotope labeling can be used to verify the presence and regulation pathway of exogenous plant miRNA.

Results: Only based on a comprehensive analysis to human high-throughput miRNA data, establishing cross-kingdom regulation model and designing effective biological experiments, can we reveal the existence, access pathways and regulation of exogenous plant miRNAs.

Conclusion: Here, we reviewed the most recent advances in the presence and pathway of exogenous plant miRNAs into human and their cross-kingdom regulation.

Keywords: Exogenous miRNAs, cross-kingdom regulation, absorption mechanism, expression level, RT-PCR, fluorescent labeling, isotope labeling.

Graphical Abstract
[1]
Huang Y, Shen XJ, Zou Q, Wang SP, Tang SM, Zhang GZ. Biological functions of microRNAs: a review. J Physiol Biochem 2011; 67(1): 129-39.
[2]
Shu J, Chiang K, Zempleni J, Cui J. Computational characterization of exogenous microRNAs that can be transferred into human circulation. PLoS One 2015; 10(11): e0140587.
[3]
Weiberg A, Wang M, Lin FM, et al. Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways. Science 2013; 342(6154): 118-23.
[4]
Hutvágner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme complex. Science 2002; 297(5589): 2056-60.
[5]
Zhang L, Hou D, Chen X, et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 2012; 22(1): 107-26.
[6]
Liang G, Zhu Y, Sun B, et al. Assessing the survival of exogenous plant microRNA in mice. Food Sci Nutr 2014; 2(4): 380-8.
[7]
Pastrello C, Tsay M, McQuaid R, et al. Circulating plant miRNAs can regulate human gene expression in vitro. Sci Rep 2016; 6: 32773.
[8]
Zhang Y, Wiggins BE, Lawrence C, Petrick J, Ivashuta S, Heck G. Analysis of plant-derived miRNAs in animal small RNA datasets. BMC Genomics 2012; 13(1): 381.
[9]
Huang Y, Zou Q, Tang SM, Wang LG, Shen XJ. Computational identification and characteristics of novel microRNAs from the silkworm (Bombyx mori L.). Mol Biol Rep 2010; 37(7): 3171-6.
[10]
Petrick JS, Brower-Toland B, Jackson AL, Kier LD. Safety assessment of food and feed from biotechnology-derived crops employing RNA-mediated gene regulation to achieve desired traits: a scientific review. Regul Toxicol Pharmacol 2013; 66(2): 167-76.
[11]
Snow JW, Hale AE, Isaacs SK, Baggish AL, Chan SY. Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA Biol 2013; 10(7): 1107-16.
[12]
Dickinson B, Zhang Y, Petrick JS, Heck G, Ivashuta S, Marshall WS. Lack of detectable oral bioavailability of plant microRNAs after feeding in mice. Nat Biotechnol 2013; 31(11): 965-7.
[13]
Witwer KW, McAlexander MA, Queen SE, Adams RJ. Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. RNA Biol 2013; 10(7): 1080-6.
[14]
Liang H, Zen K, Zhang J, Zhang CY, Chen X. New roles for microRNAs in cross-species communication. RNA Biol 2013; 10(3): 367-70.
[15]
Liu H, Wang X, Wang HD, et al. Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. Nat Commun 2012; 3: 1073.
[16]
Boss IW, Nadeau PE, Abbott JR, Yang Y, Mergia A, Renne R. A Kaposi’s sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rγnull mice. J Virol 2011; 85(19): 9877-86.
[17]
Otsuka M, Jing Q, Georgel P, et al. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity 2007; 27(1): 123-34.
[18]
Chen X, Gao C, Li H, et al. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res 2010; 20(10): 1128-37.
[19]
Zhou Z, Li X, Liu J, et al. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Res 2015; 25(1): 39-49.
[20]
Zhang Y, Liu D, Chen X, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 2010; 39(1): 133-44.
[21]
Chen X, Liang H, Zhang J, Zen K, Zhang CY. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol 2012; 22(3): 125-32.
[22]
Shu J, Chiang K, Zhao D, Cui J. Human absorbable microRNA prediction based on an ensemble manifold ranking model. 2015 IEEE International Conference on Bioinformatics and Biomedicine(BIBM). 2015 Nov 9-12; Washington, USA. 2015;
[23]
Zhu K, Liu M, Fu Z, et al. Plant microRNAs in larval food regulate honeybee caste development. PLoS Genet 2017; 13(8): e1006946.
[24]
Zhang H, Li Y, Liu Y, et al. Role of plant MicroRNA in cross-species regulatory networks of humans. BMC Syst Biol 2016; 10(1): 60.
[25]
Lecellier CH, Dunoyer P, Arar K, et al. A cellular microRNA mediates antiviral defense in human cells. Science 2005; 308(5721): 557-60.
[26]
Zhang GL, Li YX, Zheng SQ, Liu M, Li X, Tang H. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res 2010; 88(2): 169-75.
[27]
Duraisingh MT, Lodish HF. Sickle cell microRNAs inhibit the malaria parasite. Cell Host Microbe 2012; 12(2): 127-8.
[28]
Chin AR, Fong MY, Somlo G, et al. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res 2016; 26(2): 217-28.
[29]
Liang H, Zhang S, Fu Z, et al. Effective detection and quantification of dietetically absorbed plant microRNAs in human plasma. J Nutr Biochem 2015; 26(5): 505-12.
[30]
Yang J, Farmer LM, Agyekum AAA, Elbaz-Younes I, Hirschi KD. Detection of an abundant plant-based small RNA in healthy consumers. PLoS One 2015; 10(9): e0137516.
[31]
Chen X, Zen K, Zhang CY. Reply to Lack of detectable oral bioavailability of plant microRNAs after feeding in mice. Nat Biotechnol 2013; 31(11): 967-9.
[32]
Liang RQ, Li W, Li Y, et al. An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe. Nucleic Acids Res 2005; 33(2): e17-7.
[33]
Babak T, Zhang W, Morris Q, Blencowe BJ, Hughes TR. Probing microRNAs with microarrays: tissue specificity and functional inference. RNA 2004; 10(11): 1813-9.
[34]
Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA 2003; 9(10): 1274-81.
[35]
Zou Q, Li J, Hong Q, et al. Prediction of microRNA-disease associations based on social network analysis methods. BioMed Res Int 2015; 2015: 810514.
[36]
Tang W, Wan S, Yang Z, Teschendorff AE, Zou Q. Tumor origin detection with tissue-specific miRNA and DNA methylation markers. Bioinformatics 2018; 34(3): 398-406.
[37]
Zeng X, Zhang X, Zou Q. Integrative approaches for predicting microRNA function and prioritizing disease-related microRNA using biological interaction networks. Brief Bioinform 2016; 17(2): 193-203.
[38]
Tang W, Liao Z, Zou Q. Which statistical significance test best detects oncomiRNAs in cancer tissues? An exploratory analysis. Oncotarget 2016; 7(51): 85613-23.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy