Abstract
The eukaryotic translation initiation factor 4E (eIF4E) is dysregulated in a wide variety of cancers. Higher expression of eIF4E promotes tumorigenesis and has been implicated in cancer development and progression. Regulation of eIF4E is particularly controlled through phosphorylation yielding phospho-eIF4E (p-eIF4E). p-eIF4E is a signaling molecule that participates in several pathways, including regulating various cancer-related processes. The role of phosphorylation of eIF4E at Serine 209 on oncogenic transformation has been appreciated for the last 10 years and has been under active investigation as a therapeutic target for cancers including acute myeloid leukemia (AML), but the expression of p-eIF4E in the nucleus and the specific molecular mechanism of action remain largely unresolved. It is selectively and highly expressed in AML where its expression was associated with poor outcomes and prognosis. The purpose of this review is to describe p-eIF4E as an indicator prognosis and a potential anticancer target for biological therapy of AML.
Keywords: Eukaryotic translation initiation factor 4E, p-eIF4E, increased p-eIF4E levels, therapeutic target, acute myeloid leukemia, prognosis.
Current Protein & Peptide Science
Title:Phospho-eIF4E: A New Target for Acute Myeloid Leukemia
Volume: 22 Issue: 4
Author(s): Xiaofeng Jia and Hong Zhou*
Affiliation:
- Department of Hematology, Affiliated Hangzhou First peolpe’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006,China
Keywords: Eukaryotic translation initiation factor 4E, p-eIF4E, increased p-eIF4E levels, therapeutic target, acute myeloid leukemia, prognosis.
Abstract: The eukaryotic translation initiation factor 4E (eIF4E) is dysregulated in a wide variety of cancers. Higher expression of eIF4E promotes tumorigenesis and has been implicated in cancer development and progression. Regulation of eIF4E is particularly controlled through phosphorylation yielding phospho-eIF4E (p-eIF4E). p-eIF4E is a signaling molecule that participates in several pathways, including regulating various cancer-related processes. The role of phosphorylation of eIF4E at Serine 209 on oncogenic transformation has been appreciated for the last 10 years and has been under active investigation as a therapeutic target for cancers including acute myeloid leukemia (AML), but the expression of p-eIF4E in the nucleus and the specific molecular mechanism of action remain largely unresolved. It is selectively and highly expressed in AML where its expression was associated with poor outcomes and prognosis. The purpose of this review is to describe p-eIF4E as an indicator prognosis and a potential anticancer target for biological therapy of AML.
Export Options
About this article
Cite this article as:
Jia Xiaofeng and Zhou Hong *, Phospho-eIF4E: A New Target for Acute Myeloid Leukemia, Current Protein & Peptide Science 2021; 22 (4) . https://dx.doi.org/10.2174/1389203722666210219150737
DOI https://dx.doi.org/10.2174/1389203722666210219150737 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chemoprevention of Skin Cancer: Effect of Lawsonia inermis L. (Henna) Leaf Powder and its Pigment Artifact, Lawsone in the Epstein- Barr Virus Early Antigen Activation Assay and in Two-Stage Mouse Skin Carcinogenesis Models
Anti-Cancer Agents in Medicinal Chemistry Oncogene-Blocking Therapies: New Insights from Conditional Mouse Tumor Models
Current Cancer Drug Targets A Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of Repurposing Incretin-based Therapies for Breast Cancer
Current Cancer Drug Targets Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management
Current Medicinal Chemistry The Modulating Effects of Endogenous Substances on Drug Metabolising Enzymes and Implications for Inter-Individual Variability and Quantitative Prediction
Current Drug Metabolism The Ovary Feels Fine when Paracrine and Autocrine Networks Cooperate with Gonadotropins in the Regulation of Folliculogenesis
Current Pharmaceutical Design Personalization of Targeted Therapy in Advanced Thyroid Cancer
Current Genomics Evidence of PKC Binding and Translocation to Explain the Anticancer Mechanism of Chlorogenic Acid in Breast Cancer Cells
Current Molecular Medicine Application of NKT Cells in Immunotherapy
Current Immunology Reviews (Discontinued) Novel Biomarkers of microRNAs in Gastric Cancer: An Overview from Diagnosis to Treatment
MicroRNA Heterogeneous Gene Expression Cross-Evaluation of Robust Biomarkers Using Machine Learning Techniques Applied to Lung Cancer
Current Bioinformatics Nanotechology-Based Strategies to Enhance the Efficacy of Photodynamic Therapy for Cancers
Current Drug Metabolism Bruton's Tyrosine Kinase Inhibition in the Treatment of Preclinical Models and Multiple Sclerosis
Current Pharmaceutical Design Prognostic Impact of Tissue Inhibitor of Metalloproteinase-1 in Non- Small Cell Lung Cancer: Systematic Review and Meta-Analysis
Current Medicinal Chemistry Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects
Current Medicinal Chemistry Signal Transducer and Activator of Transcription 3 Signaling Pathway: A Potential Target in Sarcoma Treatment
Current Enzyme Inhibition Role of MMPs in Metastatic Dissemination: Implications for Therapeutic Advances
Current Pharmaceutical Biotechnology Vitamin D, Sunlight and Cancer Connection
Anti-Cancer Agents in Medicinal Chemistry Autophagy Regulators as Potential Cancer Therapeutic agents: A Review
Current Topics in Medicinal Chemistry The Quinoline Imidoselenocarbamate EI201 Blocks the AKT/mTOR Pathway and Targets Cancer Stem Cells Leading to a Strong Antitumor Activity
Current Medicinal Chemistry