Abstract
Imidazole has an important five-membered aromatic heterocyclic ring, which is available widely in natural products and synthetic molecules. The special structural characteristics of imidazole ring enable it to bind with a variety of enzymes and receptors through hydrogen bonds, coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces. These interactions promote several biological activities involving anti-tumor, anti-inflammatory, anti-microbial, and anti-viral properties. Herein, we review and discuss recent developments in using imidazole derivatives and their special pharmacological activities for the treatment of various diseases.
Keywords: Imidazole derivatives, Antitumor, Anti-inflammatory, Anti-microbial, Antiviral, Therapeutic drugs.
Current Topics in Medicinal Chemistry
Title:Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs
Volume: 21 Issue: 28
Author(s): Fanjie Hu, Lina Zhang, Kutty Selva Nandakumar and Kui Cheng*
Affiliation:
- Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515,China
Keywords: Imidazole derivatives, Antitumor, Anti-inflammatory, Anti-microbial, Antiviral, Therapeutic drugs.
Abstract: Imidazole has an important five-membered aromatic heterocyclic ring, which is available widely in natural products and synthetic molecules. The special structural characteristics of imidazole ring enable it to bind with a variety of enzymes and receptors through hydrogen bonds, coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces. These interactions promote several biological activities involving anti-tumor, anti-inflammatory, anti-microbial, and anti-viral properties. Herein, we review and discuss recent developments in using imidazole derivatives and their special pharmacological activities for the treatment of various diseases.
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Cite this article as:
Hu Fanjie , Zhang Lina , Nandakumar Selva Kutty and Cheng Kui *, Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs, Current Topics in Medicinal Chemistry 2021; 21 (28) . https://dx.doi.org/10.2174/1568026621666210527103225
DOI https://dx.doi.org/10.2174/1568026621666210527103225 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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