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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

The Therapeutic Potential of Targeting Autophagy in the Treatment of Cancer

Author(s): Negin Chaeichi-Tehrani, Gordon A. Ferns, Seyed Mahdi Hassanian, Majid Khazaei* and Amir Avan

Volume 21, Issue 9, 2021

Published on: 01 June, 2021

Page: [725 - 736] Pages: 12

DOI: 10.2174/1568009621666210601113144

Price: $65

Abstract

Autophagy is a mechanism by which unwanted cellular components are degraded through a pathway that involves the lysosomes and contributes to several pathological conditions such as cancer. Gastrointestinal cancers affect the digestive organs from the esophagus to the anus and are among the most commonly diagnosed cancers globally. The modulation of autophagy using pharmacologic agents offers a great potential for cancer therapy. In this review, some commonly used compounds, together with their molecular target and the mechanism through which they stimulate or block the autophagy pathway, as well as their therapeutic benefit in treating patients with gastrointestinal cancers, are summarized.

Keywords: Autophagy, lysosomes, pharmacologic agents, gastrointestinal cancers, therapeutic potential, chemotherapeutic drug.

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