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Review Article

N-Terminal Pro-C-Type Natriuretic Peptide: The Novel Marker in Selected Disease Units

Author(s): Ryszard Tomasiuk*

Volume 29, Issue 2, 2022

Published on: 15 February, 2022

Page: [125 - 132] Pages: 8

DOI: 10.2174/0929866528666211125104944

Price: $65

Abstract

Amino-terminal pro-C-type natriuretic peptide (NT-proCNP) is the N-terminal fragment of the CNP precursor. NT-proCNP occurs in an equimolar concentration with CNP in human plasma and is considered to be a marker of the extent of CNP biosynthesis. A recent study has shown associations between plasma NT-proCNP and blood pressure; it is also an independent predictor of death and cardiac readmission in people with unstable angina. Beyond that, recent studies have focused on the applicability of assessing NT-proCNP peptide levels in the diagnosis of diseases with different etiologies but the same denominator, i.e., inflammation.

This study reviewed recent results on the usability of NT-proCNP peptide levels in the diagnosis of diseases accompanied by statistical analysis of previously reported results.

The data obtained confirmed the applicability of the assessment of NT-proCNP levels in biological fluids in diseases, such as Parkinson's disease, sepsis, meningitis, and asthenozoospermia.

The reported results demonstrated that NT-proCNP is helpful in a variety of diseases. Furthermore, changes in serum or CSF levels of NT-proCNP reflect only inflammatory states related to general inflammation. Local inflammation does not trigger an increase in NT-proCNP level.

Keywords: NT-proCNP, Parkinson's disease, sepsis, meningitis, asthenozoospermia, marker.

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