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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

Nurse-led and Interdisciplinary Secondary Cardiovascular Prevention Programmes: Spanish Cohort of the EUROACTION Project

Author(s): Cristina Buigues*, Isabel Trapero, Jose Antonio Velasco, Antonio Salvador-Sanz, Catriona Jennings, David Wood and Ana Queralt

Volume 22, Issue 13, 2022

Published on: 05 July, 2022

Page: [1319 - 1329] Pages: 11

DOI: 10.2174/1871530322666220331154354

Price: $65

Abstract

Background: Cardiovascular prevention and rehabilitation programmes (CVPRP) are a preventive tool, which can reverse unhealthy behaviours and improve risk factor management. They have been successfully implemented in a variety of settings in patients with coronary heart disease (CHD).

Objective: The objective of this study is to evaluate an interdisciplinary and nurse-led cardiovascular prevention and rehabilitation programme in patients with coronary heart disease.

Methods: Six pairs of hospitals were randomised between intervention (INT) and usual care (UC) patients. The interdisciplinary team in the intervention hospital carried out a 16-week CVPRP to reach European risk factor goals. The trial is registered as ISRCTN 71715857.

Results: The proportion of patients achieving European cardiovascular recommendations in Spain increased in the intervention hospital, mainly regarding fruit and vegetable consumption (INT 98% vs. UC 53%, p<0.001), oily fish consumption (INT 42% vs. UC 19.5%, p<0.001), self-reported physical activity (INT 31% vs. UC 12.4%, p=0.04), blood pressure (INT 69% vs. UC 47.1%) p< 0.05) and LDL concentrations (INT 86.1% vs. UC 67.6%, p=0.04).

Conclusion: The EUROACTION nurse-led model of CVPR programme has shown that therapeutic goals in cardiovascular disease prevention are affordable and sustainable in everyday clinical practice. EUROACTION model adapted in Spain has produced a healthier lifestyle.

Keywords: Nursing, cardiovascular prevention and rehabilitation programme, interdisciplinary coronary heart disease, EUROACTION, healthier lifestyle, LDL.

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[1]
Kotseva, K.; De Backer, G.; De Bacquer, D.; Rydén, L.; Hoes, A.; Grobbee, D.; Maggioni, A.; Marques-Vidal, P.; Jennings, C.; Abreu, A.; Aguiar, C.; Badariene, J.; Bruthans, J.; Castro Conde, A.; Cifkova, R.; Crowley, J.; Davletov, K.; Deckers, J.; De Smedt, D.; De Sutter, J.; Dilic, M.; Dolzhenko, M.; Dzerve, V.; Erglis, A.; Fras, Z.; Gaita, D.; Gotcheva, N.; Heuschmann, P.; Hasan-Ali, H.; Jankowski, P.; Lalic, N.; Lehto, S.; Lovic, D.; Mancas, S.; Mellbin, L.; Milicic, D.; Mirrakhimov, E.; Oganov, R.; Pogosova, N.; Reiner, Z.; Stöerk, S. Tokgözoğlu, L.; Tsioufis, C.; Vulic, D.; Wood, D. EUROASPIRE Investigators*. Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry. Eur. J. Prev. Cardiol., 2019, 26(8), 824-835.
[http://dx.doi.org/10.1177/2047487318825350] [PMID: 30739508]
[2]
Kotseva, K.; Wood, D.; De Backer, G.; De Bacquer, D.; Pyörälä, K.; Keil, U. EUROASPIRE Study Group. Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries. Lancet, 2009, 373(9667), 929-940.
[http://dx.doi.org/10.1016/S0140-6736(09)60330-5] [PMID: 19286092]
[3]
Piepoli, M.F.; Hoes, A.W.; Agewall, S.; Albus, C.; Brotons, C.; Catapano, A.L.; Cooney, M-T.; Corrà, U.; Cosyns, B.; Deaton, C.; Graham, I.; Hall, M.S.; Hobbs, F.D.R.; Løchen, M.L.; Löllgen, H.; Marques-Vidal, P.; Perk, J.; Prescott, E.; Redon, J.; Richter, D.J.; Sattar, N.; Smulders, Y.; Tiberi, M.; van der Worp, H.B.; van Dis, I.; Verschuren, W.M.M.; Binno, S. ESC Scientific Document Group. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The sixth joint task force of the european society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the european association for cardiovascular prevention & rehabilitation (EACPR). Eur. Heart J., 2016, 37(29), 2315-2381.
[http://dx.doi.org/10.1093/eurheartj/ehw106] [PMID: 27222591]
[4]
Kotseva, K.; Wood, D.; De Bacquer, D.; De Backer, G.; Rydén, L.; Jennings, C.; Gyberg, V.; Amouyel, P.; Bruthans, J.; Castro Conde, A.; Cífková, R.; Deckers, J.W.; De Sutter, J.; Dilic, M.; Dolzhenko, M.; Erglis, A.; Fras, Z.; Gaita, D.; Gotcheva, N.; Goudevenos, J.; Heuschmann, P.; Laucevicius, A.; Lehto, S.; Lovic, D. Miličić D.; Moore, D.; Nicolaides, E.; Oganov, R.; Pajak, A.; Pogosova, N.; Reiner, Z.; Stagmo, M.; Störk, S.; Tokgözoğlu, L.; Vulic, D. EUROASPIRE Investigators. EUROASPIRE IV: A european society of cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. Eur. J. Prev. Cardiol., 2016, 23(6), 636-648.
[http://dx.doi.org/10.1177/2047487315569401] [PMID: 25687109]
[5]
Grau, M.; Elosua, R.; Cabrera de León, A.; Guembe, M.J.; Baena-Díez, J.M.; Vega Alonso, T.; Javier Félix, F.; Zorrilla, B.; Rigo, F.; Lapetra, J.; Gavrila, D.; Segura, A.; Sanz, H.; Fernández-Bergés, D.; Fitó, M.; Marrugat, J. [Cardiovascular risk factors in Spain in the first decade of the 21st Century, a pooled analysis with individual data from 11 population-based studies: The DARIOS study] Rev. Esp. Cardiol., 2011, 64(4), 295-304.
[http://dx.doi.org/10.1016/j.recesp.2010.11.005] [PMID: 21397375]
[6]
Redón, J.; Usó, R.; Trillo, J.L.; López, C.; Morales-Olivas, F.; Navarro, J.; Sanchís, J.; Gil, V.; Orozco-Beltrán, D. Number of drugs used in secondary cardiovascular prevention and late survival in the population of Valencia Community, Spain. Int. J. Cardiol., 2019, 293, 260-265.
[http://dx.doi.org/10.1016/j.ijcard.2019.05.071] [PMID: 31229263]
[7]
Chiang, C.Y.; Choi, K.C.; Ho, K.M.; Yu, S.F. Effectiveness of nurse-led patient-centered care behavioral risk modification on secondary prevention of coronary heart disease: A systematic review. Int. J. Nurs. Stud., 2018, 84(April), 28-39.
[http://dx.doi.org/10.1016/j.ijnurstu.2018.04.012] [PMID: 29730084]
[8]
Peersen, K.; Munkhaugen, J.; Gullestad, L.; Liodden, T.; Moum, T.; Dammen, T.; Perk, J.; Otterstad, J.E. The role of cardiac rehabilitation in secondary prevention after coronary events. Eur. J. Prev. Cardiol., 2017, 24(13), 1360-1368.
[http://dx.doi.org/10.1177/2047487317719355] [PMID: 28664773]
[9]
Jørstad, H.T.; Minneboo, M.; Helmes, H.J.M.; Fagel, N.D.; Scholte Op Reimer, W.J.; Tijssen, J.G.; Peters, R.J. Effects of a nurse-coordinated prevention programme on health-related quality of life and depression in patients with an acute coronary syndrome: Results from the RESPONSE randomised controlled trial. BMC Cardiovasc. Disord., 2016, 16(1), 144.
[http://dx.doi.org/10.1186/s12872-016-0321-4] [PMID: 27391321]
[10]
Ögmundsdottir Michelsen, H.; Nilsson, M.; Scherstén, F.; Sjölin, I.; Schiopu, A.; Leosdottir, M. Tailored nurse-led cardiac rehabilitation after myocardial infarction results in better risk factor control at one year compared to traditional care: A retrospective observational study. BMC Cardiovasc. Disord., 2018, 18(1), 167.
[http://dx.doi.org/10.1186/s12872-018-0907-0] [PMID: 30111283]
[11]
van Halewijn, G.; Deckers, J.; Tay, H.Y.; van Domburg, R.; Kotseva, K.; Wood, D. Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis. Int. J. Cardiol., 2017, 232, 294-303.
[http://dx.doi.org/10.1016/j.ijcard.2016.12.125] [PMID: 28094128]
[12]
Jennings, C.; Astin, F. A multidisciplinary approach to prevention. Eur. J. Prev. Cardiol., 2017, 24(3)(Suppl.), 77-87.
[http://dx.doi.org/10.1177/2047487317709118] [PMID: 28618913]
[13]
Murray, K.A.; Murphy, D.J.; Clements, S-J.; Brown, A.; Connolly, S.B. Comparison of uptake and predictors of adherence in primary and secondary prevention of cardiovascular disease in a community-based cardiovascular prevention programme (MyAction Westminster). J. Public Health (Oxf.), 2014, 36(4), 644-650.
[http://dx.doi.org/10.1093/pubmed/fdt118] [PMID: 24338795]
[14]
O’Toole, K.; Chamberlain, D.; Giles, T. Exploration of a nurse practitioner-led phase two cardiac rehabilitation programme on attendance and compliance. J. Clin. Nurs., 2020, 29(5-6), 785-793.
[http://dx.doi.org/10.1111/jocn.15133] [PMID: 31793120]
[15]
Brørs, G.; Pettersen, T.R.; Hansen, T.B.; Fridlund, B.; Hølvold, L.B.; Lund, H.; Norekvål, T.M. Modes of e-Health delivery in secondary prevention programmes for patients with coronary artery disease: A systematic review. BMC Health Serv. Res., 2019, 19(1), 364.
[http://dx.doi.org/10.1186/s12913-019-4106-1] [PMID: 31182100]
[16]
Park, M.; Song, R.; Jeong, J.O. Effect of goal attainment theory based education program on cardiovascular risks, behavioral modification, and quality of life among patients with first episode of acute myocardial infarction: Randomized study. Int. J. Nurs. Stud., 2017, 71, 8-16.
[http://dx.doi.org/10.1016/j.ijnurstu.2017.02.019] [PMID: 28279854]
[17]
Cano de la Cuerda, R.; Alguacil Diego, I.M.; Alonso Martín, J.J.; Molero Sánchez, A.; Miangolarra Page, J.C. Cardiac rehabilitation programs and health-related quality of life. State of the art. Rev. Esp. Cardiol. (Engl. Ed.), 2012, 65(1), 72-79.
[http://dx.doi.org/10.1016/j.rec.2011.07.015] [PMID: 22015019]
[18]
Bravo-Escobar, R.; González-Represas, A.; Gómez-González, A.M.; Montiel-Trujillo, A.; Aguilar-Jimenez, R.; Carrasco-Ruíz, R.; Salinas-Sánchez, P. Effectiveness and safety of a home-based cardiac rehabilitation programme of mixed surveillance in patients with ischemic heart disease at moderate cardiovascular risk: A randomised, controlled clinical trial. BMC Cardiovasc. Disord., 2017, 17(1), 66.
[http://dx.doi.org/10.1186/s12872-017-0499-0] [PMID: 28219338]
[19]
Cortés-Beringola, A.; Fitzsimons, D.; Pelliccia, A.; Moreno, G.; Martín-Asenjo, R.; Bueno, H. Planning secondary prevention: Room for improvement. Eur. J. Prev. Cardiol., 2017, 24(Suppl. 3), 22-28.
[http://dx.doi.org/10.1177/2047487317704954] [PMID: 28618903]
[20]
Wood, D.A. EUROACTION: A European society of cardiology demonstration project in preventive cardiology.: A cluster randomised controlled trial of a multi-disciplinary preventive cardiology programme for coronary patients, asymptomatic high risk individuals and their. Eur. Heart J. Suppl., 2004, 6(Suppl. 3), j3-j15.
[http://dx.doi.org/10.1093/eurheartj/6.suppl_j.j3]
[21]
Wood, D.A.; Kotseva, K.; Connolly, S.; Jennings, C.; Mead, A.; Jones, J.; Holden, A.; De Bacquer, D.; Collier, T.; De Backer, G.; Faergeman, O. EUROACTION Study Group. Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: A paired, cluster-randomised controlled trial. Lancet, 2008, 371(9629), 1999-2012.
[http://dx.doi.org/10.1016/S0140-6736(08)60868-5] [PMID: 18555911]
[22]
Wood, D.; De Backer, G.; Faergeman, O.; Graham, I.; Mancia, G.; Pyörälä, K. Prevention of coronary heart disease in clinical practice: Recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. Atherosclerosis, 1998, 140(2), 199-270.
[http://dx.doi.org/10.1016/S0021-9150(98)90209-X] [PMID: 9862269]
[23]
Fagerstrom, K.O.; Schneider, N.G. Measuring nicotine dependence: A review of the fagerstrom tolerance questionnaire. J. Behav. Med., 1989, 12(2), 159-182.
[http://dx.doi.org/10.1007/BF00846549] [PMID: 2668531]
[24]
Mead, A.; Atkinson, G.; Albin, D.; Alphey, D.; Baic, S.; Boyd, O.; Cadigan, L.; Clutton, L.; Craig, L.; Flanagan, C.; Greene, P.; Griffiths, E.; Lee, N.J.; Li, M.; McKechnie, L.; Ottaway, J.; Paterson, K.; Perrin, L.; Rigby, P.; Stone, D.; Vine, R.; Whitehead, J.; Wray, L.; Hooper, L. UK Heart Health Group. Thoracic Dietitians Interest Group (Specialist group of the British Dietetic Association). Dietetic guidelines on food and nutrition in the secondary prevention of cardiovascular disease - evidence from systematic reviews of randomized controlled trials (second update, January 2006). J. Hum. Nutr. Diet., 2006, 19(6), 401-419.
[http://dx.doi.org/10.1111/j.1365-277X.2006.00726.x] [PMID: 17105538]
[25]
Tian, J.; Qiu, M.; Li, Y.; Zhang, X.; Wang, H.; Sun, S.; Sharp, N.S.; Tong, W.; Zeng, H.; Zheng, S.; Song, X.; Wang, W.; Ning, G. Contribution of birth weight and adult waist circumference to cardiovascular disease risk in a longitudinal study. Sci. Rep., 2017, 7(1), 9768.
[http://dx.doi.org/10.1038/s41598-017-10176-6] [PMID: 28852140]
[26]
Blair, S.N.; Haskell, W.L.; Ho, P.; Paffenbarger, R.S.J., Jr; Vranizan, K.M.; Farquhar, J.W.; Wood, P.D. Assessment of habitual physical activity by a seven-day recall in a community survey and controlled experiments. Am. J. Epidemiol., 1985, 122(5), 794-804.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a114163] [PMID: 3876763]
[27]
Sallis, J.F.; Haskell, W.L.; Wood, P.D.; Fortmann, S.P.; Rogers, T.; Blair, S.N.; Paffenbarger, Jr. R.S. Physical activity assessment methodology in the five-city project. Am. J. Epidemiol., 1985, 121(1), 91-106.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a113987] [PMID: 3964995]
[28]
Zuazagoitia, A.; Montoya, I.; Grandes, G.; Arietaleanizbeascoa, M.S.; Arce, V.; Martinez, V.; Sanchez, M.; Sanchez, A. Reliability and validity of the 7-day physical activity recall interview in a spanish population. Eur. J. Sport Sci., 2014, 14(sup1)(Suppl. 1), S361-S368.
[http://dx.doi.org/10.1080/17461391.2012.705332] [PMID: 24444230]
[29]
Singh, S.J.; Morgan, M.D.; Scott, S.; Walters, D.; Hardman, A.E. Development of a shuttle walking test of disability in patients with chronic airways obstruction. Thorax, 1992, 47(12), 1019-1024.
[http://dx.doi.org/10.1136/thx.47.12.1019] [PMID: 1494764]
[30]
Ware, J.E.J., Jr; Sherbourne, C.D. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med. Care, 1992, 30(6), 473-483.
[http://dx.doi.org/10.1097/00005650-199206000-00002] [PMID: 1593914]
[31]
Kotseva, K.; Wood, D.A.; De Backer, G.; De Bacquer, D.; Pyöräla, K.; Keil, U. EUROASPIRE II Study Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Euro Heart Survey Programme. Eur. Heart J., 2001, 22(7), 554-572.
[http://dx.doi.org/10.1053/euhj.2001.2610] [PMID: 11259143]
[32]
Buigues, C.; Queralt, A.; De Velasco, J.A.; Salvador-Sanz, A.; Jennings, C.; Wood, D.; Trapero, I. Lipid profile results after cardiovascular prevention programme: Euroaction model in spain. Endocr. Metab. Immune Disord. Drug Targets, 2020, 20(9), 1412-1418.
[http://dx.doi.org/10.2174/1871530320666200610161344] [PMID: 32520696]
[33]
Buigues, C.; Queralt, A.; De Velasco, J.A.; Salvador-Sanz, A.; Jennings, C.; Wood, D.; Trapero, I. Psycho-social factors in patients with cardiovascular disease attending a family-centred prevention and rehabilitation programme: EUROAction model in spain. Life (Basel), 2021, 11(2), 89.
[http://dx.doi.org/10.3390/life11020089] [PMID: 33530575]
[34]
Jorstad, H.T.; von Birgelen, C.; Alings, A.M.W.; Liem, A.; van Dantzig, J.M.; Jaarsma, W.; Lok, D.J.A.; Kragten, H.J.A.; de Vries, K.; de Milliano, P.A.R.; Withagen, A.J.; Scholte Op Reimer, W.J.; Tijssen, J.G.; Peters, R.J. Effect of a nurse-coordinated prevention programme on cardiovascular risk after an acute coronary syndrome: Main results of the RESPONSE randomised trial. Heart, 2013, 99(19), 1421-1430.
[http://dx.doi.org/10.1136/heartjnl-2013-303989] [PMID: 23813851]
[35]
Georgousopoulou, E.N.; Panagiotakos, D.B.; Pitsavos, C.; Stefanadis, C. ATTICA study group. Assessment of diet quality improves the classification ability of cardiovascular risk score in predicting future events: The 10-year follow-up of the ATTICA study (2002-2012). Eur. J. Prev. Cardiol., 2015, 22(11), 1488-1498.
[http://dx.doi.org/10.1177/2047487314555095] [PMID: 25316412]
[36]
Salas-Salvadó, J.; Díaz-López, A.; Ruiz-Canela, M.; Basora, J.; Fitó, M.; Corella, D.; Serra-Majem, L.; Wärnberg, J.; Romaguera, D.; Estruch, R.; Vidal, J.; Martínez, J.A.; Arós, F.; Vázquez, C.; Ros, E.; Vioque, J.; López-Miranda, J.; Bueno-Cavanillas, A.; Tur, J.A.; Tinahones, F.J.; Martín, V.; Lapetra, J.; Pintó, X.; Daimiel, L.; Delgado-Rodríguez, M.; Matía, P.; Gómez-Gracia, E.; Díez-Espino, J.; Babio, N.; Castañer, O.; Sorlí, J.V.; Fiol, M.; Zulet, M.Á.; Bulló, M.; Goday, A.; Martínez-González, M.Á. PREDIMED-Plus investigators. Effect of a lifestyle intervention program with energy-restricted mediterranean diet and exercise on weight loss and cardiovascular risk factors: One-year results of the predimed-plus trial. Diabetes Care, 2019, 42(5), 777-788.
[http://dx.doi.org/10.2337/dc18-0836] [PMID: 30389673]
[37]
Leung, Y.W.; Ceccato, N.; Stewart, D.E.; Grace, S.L. A prospective examination of patterns and correlates of exercise maintenance in coronary artery disease patients. J. Behav. Med., 2007, 30(5), 411-421.
[http://dx.doi.org/10.1007/s10865-007-9117-4] [PMID: 17616799]
[38]
Fitzsimons, D. Stępińska, J.; Kerins, M.; Piepoli, F.M; Hill, L.; Carson, M. A.; Prescott, E. Secondary prevention and cardiovascular care across Europe: A survey of European society of cardiology Members’. Views. Eur. J. Cardiovasc. Nurs., 2020, 19(3), 201-211.
[http://dx.doi.org/10.1177/1474515119877999] [PMID: 31560214]
[39]
Mandic, S.; Body, D.; Barclay, L.; Walker, R.; Nye, E.R.; Grace, S.L.; Williams, M.J.A. Community-based cardiac rehabilitation maintenance programs: Use and effects. Heart Lung Circ., 2015, 24(7), 710-718.
[http://dx.doi.org/10.1016/j.hlc.2015.01.014] [PMID: 25797326]
[40]
Zwisler, A-D.O.; Soja, A.M.B.; Rasmussen, S.; Frederiksen, M.; Abedini, S.; Appel, J.; Rasmussen, H.; Gluud, C.; Iversen, L.; Sigurd, B.; Madsen, M.; Fischer-Hansen, J. DANREHAB Group. Hospital-based comprehensive cardiac rehabilitation versus usual care among patients with congestive heart failure, ischemic heart disease, or high risk of ischemic heart disease: 12-month results of a randomized clinical trial. Am. Heart J., 2008, 155(6), 1106-1113.
[http://dx.doi.org/10.1016/j.ahj.2007.12.033] [PMID: 18513526]
[41]
Minneboo, M.; Lachman, S.; Snaterse, M.; Jørstad, H.T.; Ter Riet, G.; Boekholdt, S.M.; Scholte Op Reimer, W.J.M.; Peters, R.J.G.; Riezebos, R.K.; van Liebergen, R.A.M.; van der Spank, A.; van Dantzig, J.M.; de Milliano, P.A.R.; van Hessen, M.W.J.; Kragten, J.A.; Jaarsma, W.; den Hartog, F.R.; Bartels, G.L.; Aengevaeren, W.R.M.; van Rossum, P.; Anneveldt, A.; de Vries, C.J. RESPONSE-2 Study Group. Community-based lifestyle intervention in patients with coronary artery disease: The respoNSE-2 trial. J. Am. Coll. Cardiol., 2017, 70(3), 318-327.
[http://dx.doi.org/10.1016/j.jacc.2017.05.041] [PMID: 28705312]
[42]
Connolly, S.B.; Kotseva, K.; Jennings, C.; Atrey, A.; Jones, J.; Brown, A.; Bassett, P.; Wood, D.A. Outcomes of an integrated community-based nurse-led cardiovascular disease prevention programme. Heart, 2017, 103(11), 840-847.
[http://dx.doi.org/10.1136/heartjnl-2016-310477] [PMID: 28255098]
[43]
Falba, T.A.; Sindelar, J.L. Spousal concordance in health behavior change. Health Serv. Res., 2008, 43(1 Pt 1), 96-116.
[http://dx.doi.org/10.1111/j.1475-6773.2007.00754.x] [PMID: 18211520]
[44]
Sher, T.; Braun, L.; Domas, A.; Bellg, A.; Baucom, D.H.; Houle, T.T. The partners for life program: A couples approach to cardiac risk reduction. Fam. Process, 2014, 53(1), 131-149.
[http://dx.doi.org/10.1111/famp.12061] [PMID: 24495204]

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