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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

A Snapshot of Current Updates and Future Prospects of 3D Printing in Medical and Pharmaceutical Science

Author(s): Rutvi Agrawal, Akash Garg and Rohitas Deshmukh*

Volume 29, Issue 8, 2023

Published on: 30 March, 2023

Page: [604 - 619] Pages: 16

DOI: 10.2174/1381612829666230228115442

Price: $65

Abstract

3D printing in other fields, such as aviation, is quite old, but in the pharmaceutical area, it is an emerging technique. 3D printing is used to formulate various drug delivery systems and dosage forms with complex geometry. It allows large and fast production of products according to the need of the patient. Today, it is the widely used manufacturing technique in the healthcare field for the engineering of tissues and tissue models, production of medicines and medical devices, organ and tissue bioprinting, implant manufacturing, and production of polypills, vaginal rings, orodispersible films, etc. It allows the production of various dosage forms with complex release profiles containing multiple active ingredients. It is used for manufacturing medicines according to the need of individual patients focusing on the concept of personalized medicines. The idea of customized medicines allows change of dosage and design of the product as per individual and with decreased side effects. This review details various techniques of 3D printing used, such as stereolithography, fused deposition modeling, inkjet printing, etc., and applications and dosage forms developed with the latest patents. The significant challenges in the emergence of the 3D printing technique are the involvement of complex combinations to achieve desired properties, and also, the bioprinter involved provides slow and less resolution. The materials prepared by this technique are both biocompatible and printable, due to which additive manufacturing is increasing in the field of medicine.

Keywords: 3D printing, powder-based printing, stereolithography, inkjet printing, extrusion-based printing, pharmaceutical.

[1]
Jassim-Jaboori AH, Oyewumi M. 3D printing technology in pharmaceutical drug delivery: prospects and challenges. Biol Mat Sci 2015; 4: e141.
[2]
Horst DJ. 3D printing of pharmaceutical drug delivery systems. 3D printing materials 2018; 1: 1-5.
[3]
Wallis M, Al-Dulimi Z, Tan DK, Maniruzzaman M, Nokhodchi A. 3D printing for enhanced drug delivery: current state-of-the-art and challenges. Drug Dev Ind Pharm 2020; 46(9): 1385-401.
[http://dx.doi.org/10.1080/03639045.2020.1801714] [PMID: 32715832]
[4]
Prasad LK, Smyth H. 3D Printing technologies for drug delivery: a review. Drug Dev Ind Pharm 2016; 42(7): 1019-31.
[http://dx.doi.org/10.3109/03639045.2015.1120743] [PMID: 26625986]
[5]
Zema L, Melocchi A, Maroni A, Gazzaniga A. Three-dimensional printing of medicinal products and the challenge of personalized therapy. J Pharm Sci 2017; 106(7): 1697-705.
[http://dx.doi.org/10.1016/j.xphs.2017.03.021] [PMID: 28347731]
[6]
Lepowsky E, Tasoglu S. 3D printing for drug manufacturing: A perspective on the future of pharmaceuticals. Int J Bioprinting 2017; 4(1): 119.
[http://dx.doi.org/10.18063/ijb.v1i1.119] [PMID: 33102905]
[7]
Ventola CL. Medical applications for 3D printing: Current and projected uses. P&T 2014; 39(10): 704-11.
[PMID: 25336867]
[8]
Mohapatra S, Kar RK, Biswal PK, Bindhani SJSI. Approaches of 3D printing in current drug delivery. Sensors International 2022; 3: 100416.
[9]
Alexander AE, Wake N, Chepelev L, Brantner P, Ryan J, Wang KC. A guideline for 3D printing terminology in biomedical research utilizing ISO/ASTM standards. 3D Print Med 2021; 7: 8.
[10]
Mazzoli A. Selective laser sintering in biomedical engineering. Med Biol Eng Comput 2013; 51(3): 245-56.
[http://dx.doi.org/10.1007/s11517-012-1001-x] [PMID: 23250790]
[11]
Tan KH, Chua CK, Leong KF, et al. Scaffold development using selective laser sintering of polyetheretherketone-hydroxyapatite biocomposite blends. Biomaterials 2003; 24(18): 3115-23.
[http://dx.doi.org/10.1016/S0142-9612(03)00131-5] [PMID: 12895584]
[12]
Pardeike J, Strohmeier DM, Schrödl N, et al. Nanosuspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines. Int J Pharm 2011; 420(1): 93-100.
[http://dx.doi.org/10.1016/j.ijpharm.2011.08.033] [PMID: 21889582]
[13]
Goole J, Amighi K. 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. Int J Pharm 2016; 499(1-2): 376-94.
[http://dx.doi.org/10.1016/j.ijpharm.2015.12.071] [PMID: 26757150]
[14]
Sokolsky-Papkov M, Agashi K, Olaye A, Shakesheff K, Domb AJ. Polymer carriers for drug delivery in tissue engineering. Adv Drug Deliv Rev 2007; 59(4-5): 187-206.
[http://dx.doi.org/10.1016/j.addr.2007.04.001] [PMID: 17540473]
[15]
Jandyal A, Chaturvedi I, Wazir I, Raina A, Haq MIUJSO. 3D printing-A review of processes, materials and applications in industry 4.0. Sustainable Operations & Computers 2022; 3: 33-42.
[16]
Lee KJ, Kang A, Delfino JJ, et al. Evaluation of critical formulation factors in the development of a rapidly dispersing captopril oral dosage form. Drug Dev Ind Pharm 2003; 29(9): 967-79.
[http://dx.doi.org/10.1081/DDC-120025454] [PMID: 14606661]
[17]
Yu DG, Shen XX, Branford-White C, Zhu LM, White K, Yang XL. Novel oral fast-disintegrating drug delivery devices with predefined inner structure fabricated by three-dimensional printing. J Pharm Pharmacol 2010; 61(3): 323-9.
[http://dx.doi.org/10.1211/jpp.61.03.0006] [PMID: 19222904]
[18]
Yu DG, Branford-White C, Yang YC, Zhu LM, Welbeck EW, Yang XL. A novel fast disintegrating tablet fabricated by three-dimensional printing. Drug Dev Ind Pharm 2009; 35(12): 1530-6.
[http://dx.doi.org/10.3109/03639040903059359] [PMID: 19929213]
[19]
Wu G, Wu W, Zheng Q, Li J, Zhou J, Hu Z. Experimental study of PLLA/INH slow release implant fabricated by three dimensional printing technique and drug release characteristics in vitro. Biomed Eng Online 2014; 13(1): 97.
[http://dx.doi.org/10.1186/1475-925X-13-97] [PMID: 25038793]
[20]
Wang CC, Tejwani Motwani MR, Roach WJ, et al. Development of near zero-order release dosage forms using three-dimensional printing (3-DP) technology. Drug Dev Ind Pharm 2006; 32(3): 367-76.
[http://dx.doi.org/10.1080/03639040500519300] [PMID: 16556541]
[21]
Yu DG, Yang XL, Huang WD, Liu J, Wang YG, Xu H. Tablets with material gradients fabricated by three-dimensional printing. J Pharm Sci 2007; 96(9): 2446-56.
[http://dx.doi.org/10.1002/jps.20864] [PMID: 17497729]
[22]
Yu DG, Branford-White C, Ma ZH, Zhu LM, Li XY, Yang XL. Novel drug delivery devices for providing linear release profiles fabricated by 3DP. Int J Pharm 2009; 370(1-2): 160-6.
[http://dx.doi.org/10.1016/j.ijpharm.2008.12.008] [PMID: 19118612]
[23]
Huang W, Zheng Q, Sun W, Xu H, Yang X. Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique. Int J Pharm 2007; 339(1-2): 33-8.
[http://dx.doi.org/10.1016/j.ijpharm.2007.02.021] [PMID: 17412538]
[24]
Wu W, Zheng Q, Guo X. The controlled-releasing drug implant based on the three dimensional printing technology: Fabrication and properties of drug releasing in vivo. J Wuhan Univ Technol-Mat Sci Edit 2009; 24: 977-81.
[25]
Wu W, Zheng Q, Guo X, Sun J, Liu Y. A programmed release multi-drug implant fabricated by three-dimensional printing technology for bone tuberculosis therapy. Biomed Mater 2009; 4(6): 065005.
[http://dx.doi.org/10.1088/1748-6041/4/6/065005] [PMID: 19901446]
[26]
Lin S, Chao PY, Chien YW, et al. In vitro and in vivo evaluations of biodegradable implants for hormone replacement therapy: Effect of system design and PK-PD relationship. AAPS PharmSciTech 2001; 2(3): 55-65.
[http://dx.doi.org/10.1208/pt020316] [PMID: 14727875]
[27]
Rowe CW, Katstra WE, Palazzolo RD, Giritlioglu B, Teung P, Cima MJ. Multimechanism oral dosage forms fabricated by three dimensional printing™. J Control Release 2000; 66(1): 11-7.
[http://dx.doi.org/10.1016/S0168-3659(99)00224-2] [PMID: 10708874]
[28]
Katstra WE, Palazzolo RD, Rowe CW, Giritlioglu B, Teung P, Cima MJ. Oral dosage forms fabricated by three dimensional printing™. J Control Release 2000; 66(1): 1-9.
[http://dx.doi.org/10.1016/S0168-3659(99)00225-4] [PMID: 10708873]
[29]
Vehse M, Petersen S, Sternberg K, Schmitz KP, Seitz H. Drug delivery from poly(ethylene glycol) diacrylate scaffolds produced by DLC based micro-stereolithography. Macromolecular Symposia. Wiley Online Library 2014.
[30]
Xing JF, Zheng ML, Duan XM. Two-photon polymerization microfabrication of hydrogels: an advanced 3D printing technology for tissue engineering and drug delivery. Chem Soc Rev 2015; 44(15): 5031-9.
[http://dx.doi.org/10.1039/C5CS00278H] [PMID: 25992492]
[31]
Goyanes A, Det-Amornrat U, Wang J, Basit AW, Gaisford S. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems. J Control Release 2016; 234: 41-8.
[http://dx.doi.org/10.1016/j.jconrel.2016.05.034] [PMID: 27189134]
[32]
Wang J, Goyanes A, Gaisford S, Basit AW. Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. Int J Pharm 2016; 503(1-2): 207-12.
[http://dx.doi.org/10.1016/j.ijpharm.2016.03.016] [PMID: 26976500]
[33]
Wong KV, Hernandez A. A review of additive manufacturing. ISRN Mechanical Engineering 2012; 1-10.
[http://dx.doi.org/10.5402/2012/208760]
[34]
Holländer J, Genina N, Jukarainen H, et al. Three-dimensional printed PCL-based implantable prototypes of medical devices for controlled drug delivery. J Pharm Sci 2016; 105(9): 2665-76.
[http://dx.doi.org/10.1016/j.xphs.2015.12.012] [PMID: 26906174]
[35]
Genina N, Holländer J, Jukarainen H, Mäkilä E, Salonen J, Sandler N. Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices. Eur J Pharm Sci 2016; 90: 53-63.
[http://dx.doi.org/10.1016/j.ejps.2015.11.005] [PMID: 26545484]
[36]
Pietrzak K, Isreb A, Alhnan MA. A flexible-dose dispenser for immediate and extended release 3D printed tablets. Eur J Pharm Biopharm 2015; 96: 380-7.
[http://dx.doi.org/10.1016/j.ejpb.2015.07.027] [PMID: 26277660]
[37]
Melocchi A, Parietti F, Loreti G, Maroni A, Gazzaniga A. 3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs. J Drug Deliv Sci Technol 2015; 30(Part B): 360-7.
[38]
Weisman JA, Nicholson JC, Tappa K, Jammalamadaka U, Wilson CG, Mills DK. Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications. Int J Nanomedicine 2015; 10: 357-70.
[PMID: 25624758]
[39]
Yi HG, Choi YJ, Kang KS, et al. A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. J Control Release 2016; 238: 231-41.
[http://dx.doi.org/10.1016/j.jconrel.2016.06.015] [PMID: 27288878]
[40]
Khaled SA, Burley JC, Alexander MR, Roberts CJ. Desktop 3D printing of controlled release pharmaceutical bilayer tablets. Int J Pharm 2014; 461(1-2): 105-11.
[http://dx.doi.org/10.1016/j.ijpharm.2013.11.021] [PMID: 24280018]
[41]
Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. J Control Release 2015; 217: 308-14.
[http://dx.doi.org/10.1016/j.jconrel.2015.09.028] [PMID: 26390808]
[42]
Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of tablets containing multiple drugs with defined release profiles. Int J Pharm 2015; 494(2): 643-50.
[http://dx.doi.org/10.1016/j.ijpharm.2015.07.067] [PMID: 26235921]
[43]
Goyanes A, Buanz ABM, Basit AW, Gaisford S. Fused-filament 3D printing (3DP) for fabrication of tablets. Int J Pharm 2014; 476(1-2): 88-92.
[http://dx.doi.org/10.1016/j.ijpharm.2014.09.044] [PMID: 25275937]
[44]
Goyanes A, Kobayashi M, Martínez-Pacheco R, Gaisford S, Basit AW. Fused-filament 3D printing of drug products: Microstructure analysis and drug release characteristics of PVA-based caplets. Int J Pharm 2016; 514(1): 290-5.
[http://dx.doi.org/10.1016/j.ijpharm.2016.06.021] [PMID: 27863674]
[45]
Cui X, Boland T, D’Lima DD, Lotz MK. Thermal inkjet printing in tissue engineering and regenerative medicine. Recent Pat Drug Deliv Formul 2012; 6(2): 149-55.
[http://dx.doi.org/10.2174/187221112800672949] [PMID: 22436025]
[46]
Lewis JA. Direct ink writing of 3D functional materials. Advanced Functional Materials 2006; 16(17): 2193-204.
[47]
Skowyra J, Pietrzak K, Alhnan MA. Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. Eur J Pharm Sci 2015; 68: 11-7.
[http://dx.doi.org/10.1016/j.ejps.2014.11.009] [PMID: 25460545]
[48]
Hoy MB. 3D printing: making things at the library. Med Ref Serv Q 2013; 32(1): 93-9.
[http://dx.doi.org/10.1080/02763869.2013.749139] [PMID: 23394423]
[49]
Ozbolat IT, Yin Y. Bioprinting toward organ fabrication: challenges and future trends. IEEE Trans Biomed Eng 2013; 60(3): 691-9.
[http://dx.doi.org/10.1109/TBME.2013.2243912] [PMID: 23372076]
[50]
Bertassoni LE, Cecconi M, Manoharan V, et al. Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab Chip 2014; 14(13): 2202-11.
[http://dx.doi.org/10.1039/C4LC00030G] [PMID: 24860845]
[51]
Schubert C, van Langeveld MC, Donoso LA. Innovations in 3D printing: a 3D overview from optics to organs. Br J Ophthalmol 2014; 98(2): 159-61.
[http://dx.doi.org/10.1136/bjophthalmol-2013-304446] [PMID: 24288392]
[52]
Pati F, Gantelius J, Svahn HA. 3D bioprinting of tissue/organ models. Angew Chem Int Ed 2016; 55(15): 4650-65.
[http://dx.doi.org/10.1002/anie.201505062] [PMID: 26895542]
[53]
Bartlett S. Printing organs on demand. Lancet Respir Med 2013; 1(9): 684.
[http://dx.doi.org/10.1016/S2213-2600(13)70239-X] [PMID: 24429271]
[54]
Mertz L. Dream it, design it, print it in 3-D: What can 3-D printing do for you? IEEE Pulse 2013; 4(6): 15-21.
[http://dx.doi.org/10.1109/MPUL.2013.2279616] [PMID: 24233186]
[55]
Cui X, Breitenkamp K, Finn MG, Lotz M, D’Lima DD. Direct human cartilage repair using three-dimensional bioprinting technology. Tissue Eng Part A 2012; 18(11-12): 1304-12.
[http://dx.doi.org/10.1089/ten.tea.2011.0543] [PMID: 22394017]
[56]
Wang J, Huang D, Yu H, Cheng Y, Ren H, Zhao Y. Developing tissue engineering strategies for liver regeneration. Engineered Regeneration 2022; 3(1): 80-91.
[http://dx.doi.org/10.1016/j.engreg.2022.02.003]
[57]
Zhang B, Xue Q, Li J, et al. 3D bioprinting for artificial cornea: Challenges and perspectives. Med Eng Phys 2019; 71: 68-78.
[http://dx.doi.org/10.1016/j.medengphy.2019.05.002] [PMID: 31201014]
[58]
Holland G, Pandit A, Sánchez-Abella L, et al. Artificial cornea: Past, current, and future directions. Front Med 2021; 8: 770780.
[http://dx.doi.org/10.3389/fmed.2021.770780] [PMID: 34869489]
[59]
Duarte Campos DF, Rohde M, Ross M, et al. Corneal bioprinting utilizing collagen-based bioinks and primary human keratocytes. J Biomed Mater Res A 2019; 107(9): 1945-53.
[http://dx.doi.org/10.1002/jbm.a.36702] [PMID: 31012205]
[60]
Isaacson A, Swioklo S, Connon CJ. 3D bioprinting of a corneal stroma equivalent. Exp Eye Res 2018; 173: 188-93.
[http://dx.doi.org/10.1016/j.exer.2018.05.010] [PMID: 29772228]
[61]
Ulag S, Ilhan E, Sahin A, et al. 3D printed artificial cornea for corneal stromal transplantation. European Polymer Journal 2020; 133: 109744.
[62]
Sorkio A, Koch L, Koivusalo L, et al. Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks. Biomaterials 2018; 171: 57-71.
[http://dx.doi.org/10.1016/j.biomaterials.2018.04.034] [PMID: 29684677]
[63]
Kim KW, Lee SJ, Park SH, Kim JC. Ex vivo functionality of 3D bioprinted corneal endothelium engineered with ribonuclease 5-overexpressing human corneal endothelial cells. Adv Healthc Mater 2018; 7(18): 1800398.
[http://dx.doi.org/10.1002/adhm.201800398] [PMID: 30066447]
[64]
Park J, Lee KP, Kim H, et al. Biocompatibility evaluation of bioprinted decellularized collagen sheet implanted in vivo cornea using swept-source optical coherence tomography. J Biophotonics 2019; 12(11): e201900098.
[http://dx.doi.org/10.1002/jbio.201900098] [PMID: 31240872]
[65]
Kent C. 3D bioprinting: Is this the future of Organ transplantation? The future of bioprinting: A new frontier in regenerative healthcare.
[66]
Bertana V, Catania F, Cocuzza M, Ferrero S, Scaltrito L, Pirri C. Medical and biomedical applications of 3D and 4D printed polymer nanocomposites. 3D and 4D Printing of Polymer Nanocomposite Materials. Elsevier 2020; pp. 325-66.
[67]
Noor N, Shapira A, Edri R, Gal I, Wertheim L, Dvir T. 3D printing of personalized thick and perfusable cardiac patches and hearts. Adv Sci 2019; 6(11): 1900344.
[http://dx.doi.org/10.1002/advs.201900344] [PMID: 31179230]
[68]
Arai K, Murata D, Verissimo AR, et al. Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer. PLoS One 2018; 13(12): e0209162.
[http://dx.doi.org/10.1371/journal.pone.0209162] [PMID: 30557409]
[69]
Yadid M, Oved H, Silberman E, Dvir T. Bioengineering approaches to treat the failing heart: from cell biology to 3D printing. Nat Rev Cardiol 2022; 19(2): 83-99.
[http://dx.doi.org/10.1038/s41569-021-00603-7] [PMID: 34453134]
[70]
Nadagouda MN, Ginn M, Rastogi V. A review of 3D printing techniques for environmental applications. Curr Opin Chem Eng 2020; 28: 173-8.
[http://dx.doi.org/10.1016/j.coche.2020.08.002] [PMID: 34327115]
[71]
Javaid M, Haleem AJSI. 3D bioprinting applications for the printing of skin: A brief study. Sensors Int 2021; 2: 100123.
[72]
Ng WL, Ayi TC, Liu YC, Sing SL, Yeong WY, Tan BH. Fabrication and characterization of 3D bioprinted triple-layered human alveolar lung models. Int J Bioprinting 2021; 7(2): 332.
[http://dx.doi.org/10.18063/ijb.v7i2.332] [PMID: 33997432]
[73]
Das P. An in-vivo mimicking 3D lung cancer-on-a-chip model to study the effect of external stimulus on the progress and inhibition of cancer metastasis. Bioprinting 2022; 28: e00243.
[74]
Klein GT, Lu Y, Wang MY. 3D printing and neurosurgery--ready for prime time? World Neurosurg 2013; 80(3-4): 233-5.
[http://dx.doi.org/10.1016/j.wneu.2013.07.009] [PMID: 23871811]
[75]
Dias AD, Unser AM, Xie Y, Chrisey DB, Corr DT. Generating size-controlled embryoid bodies using laser direct-write. Biofabrication 2014; 6(2): 025007.
[http://dx.doi.org/10.1088/1758-5082/6/2/025007] [PMID: 24694373]
[76]
Michael S, Sorg H, Peck CT, et al. Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice. PLoS One 2013; 8(3): e57741.
[http://dx.doi.org/10.1371/journal.pone.0057741] [PMID: 23469227]
[77]
Banks J. Adding value in additive manufacturing: researchers in the United Kingdom and Europe look to 3D printing for customization. IEEE Pulse 2013; 4(6): 22-6.
[http://dx.doi.org/10.1109/MPUL.2013.2279617] [PMID: 24233187]
[78]
Tian Y, Chen C, Xu X, et al. A review of 3D printing in dentistry: Technologies, affecting factors, and applications. Scanning 2021; 2021: 1-19.
[http://dx.doi.org/10.1155/2021/9950131] [PMID: 34367410]
[79]
Balamurugan and Selvakumar N. Development of patient specific dental implant using 3D printing. J Ambient Intell Human Comput 2021; 12: 3549-58.
[80]
Sheela UB, Usha PG, Joseph MM, Melo JS, Nair STT, Tripathi A. 3D printing in dental implants.3D printing in medicine and surgery. Elsevier 2021; pp. 83-104.
[81]
Özkol E, Zhang W, Ebert J. Potentials of the “Direct inkjet printing” method for manufacturing 3Y-TZP based dental restorations. J Eur Ceram Soc 2012; 32(10): 2193-201.
[82]
Kondiah PJ, Kondiah PPD, Choonara YE, Marimuthu T, Pillay V. A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering. Pharmaceutics 2020; 12(2): 166.
[http://dx.doi.org/10.3390/pharmaceutics12020166] [PMID: 32079221]
[83]
Park JW, Kang HG. Application of 3-dimensional printing implants for bone tumors. Clin Exp Pediatr 2022; 65(10): 476-82.
[http://dx.doi.org/10.3345/cep.2021.01326] [PMID: 34942688]
[84]
Tappa K, Jammalamadaka U, Ballard DH, et al. Medication eluting devices for the field of OBGYN (MEDOBGYN): 3D printed biodegradable hormone eluting constructs, a proof of concept study. PLoS One 2017; 12(8): e0182929.
[http://dx.doi.org/10.1371/journal.pone.0182929] [PMID: 28797120]
[85]
Domínguez-Robles J, Mancinelli C, Mancuso E, et al. 3D printing of drug-loaded thermoplastic polyurethane meshes: A potential material for soft tissue reinforcement in vaginal surgery. Pharmaceutics 2020; 12(1): 63.
[http://dx.doi.org/10.3390/pharmaceutics12010063] [PMID: 31941047]
[86]
Fu J, Yu X, Jin Y. 3D printing of vaginal rings with personalized shapes for controlled release of progesterone. Int J Pharm 2018; 539(1-2): 75-82.
[http://dx.doi.org/10.1016/j.ijpharm.2018.01.036] [PMID: 29366944]
[87]
Domsta V, Seidlitz A. 3D-printing of drug-eluting implants: An overview of the current developments described in the literature. Molecules 2021; 26(13): 4066.
[http://dx.doi.org/10.3390/molecules26134066] [PMID: 34279405]
[88]
Markstedt K, Sundberg J, Gatenholm PJDP. 3D bioprinting of cellulose structures from an ionic liquid. 3D Printing and Additive Manufacturing 2014; 1(3): 115-21.
[89]
Flege C, Vogt F, Höges S, et al. Development and characterization of a coronary polylactic acid stent prototype generated by selective laser melting. J Mater Sci Mater Med 2013; 24(1): 241-55.
[http://dx.doi.org/10.1007/s10856-012-4779-z] [PMID: 23053808]
[90]
Wang Z, Yang Y. Application of 3D Printing in Implantable Medical Devices. BioMed Res Int 2021; 2021: 1-13.
[http://dx.doi.org/10.1155/2021/6653967] [PMID: 33521128]
[91]
Kundu J, Shim JH, Jang J, Kim SW, Cho DW. An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering. J Tissue Eng Regen Med 2015; 9(11): 1286-97.
[http://dx.doi.org/10.1002/term.1682] [PMID: 23349081]
[92]
Zhang Q, Bei HP, Zhao M, Dong Z, Zhao X. Shedding light on 3D printing: Printing photo-crosslinkable constructs for tissue engineering. Biomaterials 2022; 286: 121566.
[http://dx.doi.org/10.1016/j.biomaterials.2022.121566] [PMID: 35633590]
[93]
Luis E, Pan HM, Sing SL, Bajpai R, Song J, Yeong WY. 3D direct printing of silicone meniscus implant using a novel heat-cured extrusion-based printer. Polymers 2020; 12(5): 1031.
[http://dx.doi.org/10.3390/polym12051031] [PMID: 32370046]
[94]
Luis E, Pan HM, Bastola AK, et al. 3D printed silicone meniscus implants: influence of the 3d printing process on properties of silicone implants. Polymers 2020; 12(9): 2136.
[http://dx.doi.org/10.3390/polym12092136] [PMID: 32962059]
[95]
Chen G, Xu Y, Kwok PCL, Kang LJAM. Pharmaceutical applications of 3D printing. Addit Manuf 2020; 34: 101209.
[96]
Liaw CY, Guvendiren M. Current and emerging applications of 3D printing in medicine. Biofabrication 2017; 9(2): 024102.
[http://dx.doi.org/10.1088/1758-5090/aa7279] [PMID: 28589921]
[97]
Maroni A, Melocchi A, Parietti F, Foppoli A, Zema L, Gazzaniga A. 3D printed multi-compartment capsular devices for two-pulse oral drug delivery. J Control Release 2017; 268: 10-8.
[http://dx.doi.org/10.1016/j.jconrel.2017.10.008] [PMID: 29030223]
[98]
Gioumouxouzis CI, Baklavaridis A, Katsamenis OL, et al. A 3D printed bilayer oral solid dosage form combining metformin for prolonged and glimepiride for immediate drug delivery. Eur J Pharm Sci 2018; 120: 40-52.
[http://dx.doi.org/10.1016/j.ejps.2018.04.020] [PMID: 29678613]
[99]
Beatriz CP, Abdullah I, Mohammad I, Robert T. Forbes EFO, Alhnan MA. Additive manufacturing of a point-of-care “polypill”: Fabrication of concept capsules of complex geometry with bespoke release against cardiovascular disease. Adv Healthc Mater 2020; 9(13): e200-0236.
[100]
Niese S, Quodbach J. Formulation development of a continuously manufactured orodispersible film containing warfarin sodium for individualized dosing. Eur J Pharm Biopharm 2019; 136: 93-101.
[http://dx.doi.org/10.1016/j.ejpb.2019.01.011] [PMID: 30660692]
[101]
Öblom H, Sjöholm E, Rautamo M, Sandler N. Towards printed pediatric medicines in hospital pharmacies: Comparison of 2D and 3D-printed orodispersible warfarin films with conventional oral powders in unit dose sachets. Pharmaceutics 2019; 11(7): 334.
[http://dx.doi.org/10.3390/pharmaceutics11070334] [PMID: 31337146]
[102]
Cho H, Jammalamadaka U, Tappa K, et al. 3D printing of poloxamer 407 nanogel discs and their applications in adjuvant ovarian cancer therapy. Mol Pharm 2019; 16(2): 552-60.
[http://dx.doi.org/10.1021/acs.molpharmaceut.8b00836] [PMID: 30608705]
[103]
Spence BM, Longest W, Wei X, Dhapare S, Hindle M. Development of a high-flow nasal cannula and pharmaceutical aerosol combination device. J Aerosol Med Pulm Drug Deliv 2019; 32(4): 224-41.
[http://dx.doi.org/10.1089/jamp.2018.1488] [PMID: 30855199]
[104]
Jalili-Firoozinezhad S, Prantil-Baun R, Jiang A, et al. Modeling radiation injury-induced cell death and countermeasure drug responses in a human gut-on-a-chip. Cell Death Dis 2018; 9(2): 223.
[http://dx.doi.org/10.1038/s41419-018-0304-8] [PMID: 29445080]
[105]
Wickström H, Koppolu R, Mäkilä E, Toivakka M, Sandler N. Stencil printing—a novel manufacturing platform for orodispersible discs. Pharmaceutics 2020; 12(1): 33.
[http://dx.doi.org/10.3390/pharmaceutics12010033] [PMID: 31906316]
[106]
Rycerz K, Stepien KA, Czapiewska M, et al. Embedded 3D printing of novel bespoke soft dosage form concept for pediatrics. Pharmaceutics 2019; 11(12): 630.
[http://dx.doi.org/10.3390/pharmaceutics11120630] [PMID: 31779123]
[107]
Andriotis EG, Eleftheriadis GK, Karavasili C, Fatouros DG. Development of bio-active patches based on pectin for the treatment of ulcers and wounds using 3D-bioprinting technology. Pharmaceutics 2020; 12(1): 56.
[http://dx.doi.org/10.3390/pharmaceutics12010056] [PMID: 31936630]
[108]
Economidou SN, Lamprou DA, Douroumis D. 3D printing applications for transdermal drug delivery. Int J Pharm 2018; 544(2): 415-24.
[http://dx.doi.org/10.1016/j.ijpharm.2018.01.031] [PMID: 29355656]
[109]
Uddin MJ, Scoutaris N, Klepetsanis P, Chowdhry B, Prausnitz MR, Douroumis D. Inkjet printing of transdermal microneedles for the delivery of anticancer agents. Int J Pharm 2015; 494(2): 593-602.
[http://dx.doi.org/10.1016/j.ijpharm.2015.01.038] [PMID: 25617676]
[110]
Ross S, Scoutaris N, Lamprou D, Mallinson D, Douroumis D. Inkjet printing of insulin microneedles for transdermal delivery. Drug Deliv Transl Res 2015; 5(4): 451-61.
[http://dx.doi.org/10.1007/s13346-015-0251-1] [PMID: 26242687]
[111]
Uddin MJ, Scoutaris N, Economidou SN, et al. 3D printed microneedles for anticancer therapy of skin tumours. Mater Sci Eng C 2020; 107: 110248.
[http://dx.doi.org/10.1016/j.msec.2019.110248] [PMID: 31761175]
[112]
Ceylan H, Yasa IC, Yasa O, Tabak AF, Giltinan J, Sitti M. 3D-printed biodegradable microswimmer for theranostic cargo delivery and release. ACS Nano 2019; 13(3): 3353-62.
[http://dx.doi.org/10.1021/acsnano.8b09233] [PMID: 30742410]
[113]
Varghese R, Salvi S, Sood P, Karsiya J. 3D printed medicine for the management of chronic diseases: The road less travelled. Annals of 3D Printed Medicine 2022; 5: 100043.
[114]
Ma T, Lv L, Ouyang C, et al. Rheological behavior and particle alignment of cellulose nanocrystal and its composite hydrogels during 3D printing. Carbohydr Polym 2021; 253: 117217.
[http://dx.doi.org/10.1016/j.carbpol.2020.117217] [PMID: 33278981]
[115]
Ishack S, Lipner SR. Applications of 3D printing technology to address COVID-19–related supply shortages. Am J Med 2020; 133(7): 771-3.
[http://dx.doi.org/10.1016/j.amjmed.2020.04.002] [PMID: 32330492]
[116]
Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol 2014; 32(8): 773-85.
[http://dx.doi.org/10.1038/nbt.2958] [PMID: 25093879]

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