Synthesis and Biological Applications of Glycoconjugates

Diels-Alder Based Synthesis of Glycomimetics

Author(s): '> Cristina Nativi, Elisa Dragoni, Barbara Richichi, Stefano Roelens

Pp: 240-254 (15)

DOI: 10.2174/978160805277611101010240

* (Excluding Mailing and Handling)

Abstract

[4+2] Cycloadditions between “in situ” generated α,α-dioxothiones and unprotected or variously protected glycals provide a powerful synthetic way to obtain glycomimetics chemo-, regio- and stereoselectively. Examples of glycopeptidomimetics and mimetic of tumor antigens are reported.


Keywords: Hetero Diels-Alder, mimetics, tumor antigens, glycopeptides, matrix metalloproteinases

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