Abstract
Alzheimers disease (AD) is a genetically complex and heterogenous disorder. In a small proportion of cases, mutations in three determinative (causal) genes are responsible for autosomal dominant early-onset forms of AD. The majority of cases, however, is sporadic, late-onset AD with unknown etiology. The pathology and clinical manifestations of these forms are influenced by multiple genetic and environmental risk factors. Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD.
Keywords: Allele, Alzheimer's disease, determinative gene, linkage analysis, polymorphism, risk factor, risk gene, susceptibility gene
Current Drug Metabolism
Title: Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind...
Volume: 7 Issue: 3
Author(s): Andras Palotas and Janos Kalman
Affiliation:
Keywords: Allele, Alzheimer's disease, determinative gene, linkage analysis, polymorphism, risk factor, risk gene, susceptibility gene
Abstract: Alzheimers disease (AD) is a genetically complex and heterogenous disorder. In a small proportion of cases, mutations in three determinative (causal) genes are responsible for autosomal dominant early-onset forms of AD. The majority of cases, however, is sporadic, late-onset AD with unknown etiology. The pathology and clinical manifestations of these forms are influenced by multiple genetic and environmental risk factors. Over the past decades, a number of candidate genes have been identified as disease modifiers with conflicting results. This study reviews susceptibility genes that are associated with increased risk of developing AD.
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Cite this article as:
Palotas Andras and Kalman Janos, Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind..., Current Drug Metabolism 2006; 7 (3) . https://dx.doi.org/10.2174/138920006776359257
DOI https://dx.doi.org/10.2174/138920006776359257 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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