Abstract
In healthy individuals, natural and adaptive immune responses are able to control virus entry into the host. In particular, CD8+-mediated cytotoxicity, sustained by the intervention of CD4+ cells, represents the major key event leading to virus eradication. On the other hand, viruses are able to evade from host immune response via several mechanisms, and special emphasis will be placed on hepatitis C virus and chronic Epstein-Barr infections also in view of personal data. Virokines, viroreceptors, and serpins greatly contribute to viral immune escape, and, among virokines, interleukin (IL)-10 has been object of intensive studies. Finally, all these products have been used as biopharmaceuticals, and, for instance, viral IL-10, chemokine-binding proteins, and serpins exhibit in animal models immunosuppressive, antiinflammatory, and antiatherogenic activities. As far as their use in human trials is concernded, many cautions are required in order to avoid deleterious side effects and, in particular, the purity of the product, its route and frequency of administration, as well as the immune status of the patient should be taken into serious account.
Keywords: Chemokine, Epstein-Barr virus infection, escape, hepatis C virus infection, immunity, interleukin, serpins, virus
Current Medicinal Chemistry
Title: Taking Advantage of Viral Immune Evasion: Virus-Derived Proteins Represent Novel Biopharmaceuticals
Volume: 13 Issue: 3
Author(s): L. Amati, M. E. Passeri, A. Lippolis, D. Lio, C. Caruso, E. Jirillo and V. Covelli
Affiliation:
Keywords: Chemokine, Epstein-Barr virus infection, escape, hepatis C virus infection, immunity, interleukin, serpins, virus
Abstract: In healthy individuals, natural and adaptive immune responses are able to control virus entry into the host. In particular, CD8+-mediated cytotoxicity, sustained by the intervention of CD4+ cells, represents the major key event leading to virus eradication. On the other hand, viruses are able to evade from host immune response via several mechanisms, and special emphasis will be placed on hepatitis C virus and chronic Epstein-Barr infections also in view of personal data. Virokines, viroreceptors, and serpins greatly contribute to viral immune escape, and, among virokines, interleukin (IL)-10 has been object of intensive studies. Finally, all these products have been used as biopharmaceuticals, and, for instance, viral IL-10, chemokine-binding proteins, and serpins exhibit in animal models immunosuppressive, antiinflammatory, and antiatherogenic activities. As far as their use in human trials is concernded, many cautions are required in order to avoid deleterious side effects and, in particular, the purity of the product, its route and frequency of administration, as well as the immune status of the patient should be taken into serious account.
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Cite this article as:
Amati L., Passeri E. M., Lippolis A., Lio D., Caruso C., Jirillo E. and Covelli V., Taking Advantage of Viral Immune Evasion: Virus-Derived Proteins Represent Novel Biopharmaceuticals, Current Medicinal Chemistry 2006; 13 (3) . https://dx.doi.org/10.2174/092986706775476106
DOI https://dx.doi.org/10.2174/092986706775476106 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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