Abstract
Studies on oligodendrocytes, the myelin-forming cells of the central nervous system, and on the progenitor cells from which they are derived, have provided several novel insights into the role of intracellular redox state in cell function. A central unifying theme of this research is that redox state modulation lies at the heart of understanding cellintrinsic aspects of precursor cell function, responsiveness of precursor cells to cell-extrinsic signals and even the means by which cell-extrinsic signaling molecules alter cellular function. This review discusses our studies on the role in redox state as a critical modulator of cellular function, and considers the implications of these findings for optimizing tissue repair.
Keywords: tissue repair, myelin-forming oligodendrocytes, growth factor, N-acetyl-L-cysteine (NAC), CNS, signaling pathways
Current Alzheimer Research
Title: Implications for CNS Repair of Redox Modulation of Cell Survival, Division and Differentiation
Volume: 3 Issue: 1
Author(s): Mark Noble
Affiliation:
Keywords: tissue repair, myelin-forming oligodendrocytes, growth factor, N-acetyl-L-cysteine (NAC), CNS, signaling pathways
Abstract: Studies on oligodendrocytes, the myelin-forming cells of the central nervous system, and on the progenitor cells from which they are derived, have provided several novel insights into the role of intracellular redox state in cell function. A central unifying theme of this research is that redox state modulation lies at the heart of understanding cellintrinsic aspects of precursor cell function, responsiveness of precursor cells to cell-extrinsic signals and even the means by which cell-extrinsic signaling molecules alter cellular function. This review discusses our studies on the role in redox state as a critical modulator of cellular function, and considers the implications of these findings for optimizing tissue repair.
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Cite this article as:
Noble Mark, Implications for CNS Repair of Redox Modulation of Cell Survival, Division and Differentiation, Current Alzheimer Research 2006; 3 (1) . https://dx.doi.org/10.2174/156720506775697188
DOI https://dx.doi.org/10.2174/156720506775697188 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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